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Polyethylene Glycol

CAS No.: 25322-68-3
Formula: (C2H4O)nH2O
Molecular Weight: 0
Suppliers: All(0) China Suppliers(33) Products(65)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Price
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What is Polyethylene Glycol

Poly(ethylene glycol) (PEG) is a versatile, water-soluble polymer widely used in various industries, including pharmaceuticals, cosmetics, and biotechnology. Composed of repeating ethylene oxide units, PEG is available in a range of molecular weights, making it adaptable for diverse applications. In pharmaceuticals, it serves as an excipient in drug formulations, enhancing solubility and stability. PEG is also a key component in personal care products, acting as a moisturizer and emulsifier. Its biocompatibility and low toxicity make it ideal for biomedical applications, such as drug delivery systems and tissue engineering. PEG's ability to modify surfaces and improve biocompatibility further underscores its importance in advanced materials and nanotechnology.

Preparation Process: Poly(ethylene glycol) (PEG) is synthesized via ring-opening polymerization of ethylene oxide (EO) using an initiator (e.g., water, methanol, or ethylene glycol) and a basic or acidic catalyst (e.g., KOH or BF₃). The process involves heating EO under controlled pressure (1–5 atm) at 100–150°C. The initiator’s hydroxyl groups react with EO, forming a growing PEG chain. Molecular weight is controlled by the initiator-to-EO ratio. After polymerization, the catalyst is neutralized and removed, followed by purification via distillation or solvent extraction. PEG properties (e.g., viscosity, solubility) vary with chain length (n), adjusted by reaction conditions.

Usage Scenarios: Poly(ethylene glycol) (PEG) is a versatile polymer widely used in pharmaceuticals, cosmetics, and industrial applications. In drug delivery, PEGylation improves the solubility, stability, and circulation time of therapeutic proteins and nanoparticles. It serves as a lubricant in ointments, creams, and eye drops due to its biocompatibility and low toxicity. PEG is also employed in bioconjugation, tissue engineering, and as a precipitant in protein crystallization. Industrially, it functions as a surfactant, dispersant, and plasticizer. Additionally, PEG is used in chemical synthesis, chromatography, and as a phase-change material for thermal energy storage. Its hydrophilicity and tunable molecular weight enhance its utility across diverse fields.

Polyethylene Glycol Basic Info
Chemical Name Polyethylene Glycol
Synonyms PEG;PEO;POLYETHYLENE GLYCOL;PEG 400;POLY(ETHYLENE OXIDE);Macrogol;PEG 6000;PEG-8;PEG-12;PEG-20
CAS No. 25322-68-3
Molecular Formula (C2H4O)nH2O
Molecular Weight 0
PSA 0.00000
LogP -0.698 at 25℃
Safely Info
RTECS TQ4110000
Hazard Class -
Safety Statements 26-36-24/25-61-45-36/37
HS Code 39072011
WGK Germany -
Packing Group -
RIDADR -
Risk Statements 36/38-52/53-33-23/24/25
Hazard Codes Xi,T
Caution Statement P273-P280-P301+P312+P330-P302+P352+P312-P391-P501
Hazard Declaration H302-H311-H373-H411
Symbol GHS06,GHS08,GHS09
Signal Word Danger
Polyethylene Glycol Price
United States: $1-$10 per kg
China: $0.50-$5 per kg
Russia: No results
Germany: $5-$15 per kg
India: $2-$8 per kg
Japan: $3-$12 per kg
Brazil: $1-$7 per kg
South Korea: $2-$10 per kg
Philippines: No results
United Kingdom: $6-$20 per kg
France: $5-$15 per kg
Mexico: $2-$8 per kg
Canada: $3-$11 per kg
South Africa: $2-$9 per kg
Egypt: $1-$6 per kg
Turkey: $3-$10 per kg
Thailand: $2-$8 per kg
Indonesia: $1-$5 per kg
MSDS
MSDS

Section 1. Chemical Product and Company Identification
    Polyethylene glycol 4500        Catalog    
    XX963, P1792
    Common Name/
    Number(s).
    Trade Name
    CAS#        25322-68-3    
    Manufacturer
    RTECS        TQ4070000    
    SPECTRUM CHEMICAL MFG. CORP.
    TSCA        TSCA 8(b) inventory:    
    Polyethylene glycol 4500
    Commercial Name(s)        PEG-4500    
    CI# Not available.
    Synonym        Not available.    
    IN CASE OF EMERGENCY
    Not available.
    Chemical Name
    Chemical Family        Not available.        CALL (310) 516-8000    
    H(OCH2CH2)nOH
    Chemical Formula
    SPECTRUM CHEMICAL MFG. CORP.

Section 2.Composition and Information on Ingredients
    Exposure Limits
    TWA (mg/m3)        STEL (mg/m3) CEIL (mg/m3)    
    Name        CAS #        % by Weight    
    1) Polyethylene glycol 4500        25322-68-3        100    
    Toxicological Data        Polyethylene glycol 4500:    
    on Ingredients        ORAL (LD50):        Acute: 4000 mg/kg [Rat]. 20000 mg/kg [Mouse].    
    DERMAL (LD50): Acute: 20000 mg/kg [Rabbit].

Section 3. Hazards Identification
    Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation.
    Potential Chronic Health        CARCINOGENIC EFFECTS: Not available.    
    Effects        MUTAGENIC EFFECTS: Not available.    
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated or prolonged exposure is not known to aggravate medical condition.
    Polyethylene glycol 4500

Section 4. First Aid Measures
    Eye Contact        Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used.    
    Skin Contact        After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin    
    with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
    Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
    Wash contaminated clothing before reusing.
    Serious Skin Contact        Not available.    
    Inhalation        Allow the victim to rest in a well ventilated area. Seek immediate medical attention.    
    Serious Inhalation        Not available.    
    Ingestion        Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not    
    breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature 395°C (743°F)
    Flash Points        CLOSED CUP: 176°C (348.8°F). OPEN CUP: 223.9°C (435°F).    
    Flammable Limits        LOWER: 1.1%    
    These products are carbon oxides (CO, CO2).
    Products of Combustion
    Fire Hazards in Presence of Not available.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
    Explosive in presence of oxidizing materials.
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    Special Remarks on        Not available.    
    Fire Hazards
    Special Remarks on Explosion Not available.
    Hazards

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water    
    on the contaminated surface and allow to evacuate through the sanitary system.
    Polyethylene glycol 4500

Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the    
    residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. If
    ingested, seek medical advice immediately and show the container or the label.
    Storage        Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly    
    closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
    and away from strong oxidizing agents.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid.        Odor        Not available.    
    Not available.
    Taste
    Molecular Weight        4500 g/mole    
    Not available.
    Color
    6 [Acidic.]
    pH (1% soln/water)
    Boiling Point        Not available.    
    Melting Point        63°C (145.4°F)    
    Critical Temperature        Not available.    
    Specific Gravity        1.054 (Water = 1)    
    Not applicable.
    Vapor Pressure
    Vapor Density        Not available.    
    Not available.
    Volatility
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Dispersion Properties        See solubility in water, methanol, diethyl ether.    
    Solubility        Easily soluble in cold water.    
    Soluble in hot water, methanol, diethyl ether.

Section 10. Stability and Reactivity Data
    Stability        The product is stable.    
    Instability Temperature        Not available.    
    Conditions of Instability        Not available.    
    Incompatibility with various Not available.
    substances
    Polyethylene glycol 4500
    Corrosivity        Non-corrosive in presence of glass.    
    Special Remarks on        Not available.    
    Reactivity
    Special Remarks on        Not available.    
    Corrosivity
    Polymerization        No.    

Section 11. Toxicological Information
    Routes of Entry        Eye contact. Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 4000 mg/kg [Rat].    
    Acute dermal toxicity (LD50): 20000 mg/kg [Rabbit].
    Chronic Effects on Humans Not available.
    Other Toxic Effects on
    Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.
    Humans
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        Not available.    
    Chronic Effects on Humans
    Special Remarks on other        Not available.    
    Toxic Effects on Humans

Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may    
    arise.
    Toxicity of the Products        The products of degradation are more toxic.    
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Identification        Not applicable.    
    Special Provisions for        Not applicable.    
    Transport
    Polyethylene glycol 4500
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    Federal and State
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
    Regulations
    Polyethylene glycol 4500
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: Polyethylene glycol 4500
    TSCA 8(b) inventory: Polyethylene glycol 4500
    California        California prop. 65: This product contains the following ingredients for which the State of California has found    
    Proposition 65        to cause cancer which would require a warning under the statute: Polyethylene glycol 4500    
    Warnings
    Other Regulations        Not available..    
    Other Classifications        WHMIS (Canada) Not controlled under WHMIS (Canada).    
    DSCL (EEC)        R16- Explosive when mixed with    
    oxidizing substances.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    0 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Polyethylene glycol 4500
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0
Polyethylene Glycol Suppliers
Company Name
Business Type
Location
Details
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China Shandong Jinan
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China Liaoning Liaoyang
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China
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U.S.A
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China LiaoNing Anshan
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China Shanghai Minhang
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China Jiangsu Nanjing
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China Zhejiang Ningbo
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China Shanghai Shanghai
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Manufacturer
China Tianjin Hangu
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