Vitamin A C20H30O Properties,Formula,Price, Uses

What is Vitamin A

**Introduction to All-Trans-Retinol** All-trans-retinol, commonly known as retinol, is a gold-standard skincare ingredient renowned for its powerful anti-aging and skin-renewing properties. As a pure form of vitamin A, it stimulates collagen production, accelerates cell turnover, and reduces the appearance of fine lines, wrinkles, and hyperpigmentation. Its ability to unclog pores also makes it effective in treating acne and improving skin texture. Suitable for gradual incorporation into skincare routines, retinol works by converting to retinoic acid in the skin, delivering visible results over time. To minimize irritation, it is recommended to start with lower concentrations and use sunscreen daily, as retinol increases sun sensitivity. A dermatologist-favorite, it remains a cornerstone of evidence-based skincare.

Preparation Process: All-trans-Retinol can be prepared via the following method: 1. **Starting Material**: Begin with β-ionone, which is converted to β-C15 aldehyde via a Darzens glycidic ester condensation followed by hydrolysis and decarboxylation. 2. **Wittig Reaction**: React β-C15 aldehyde with a C5 phosphonium salt (triphenylphosphonium ylide derived from isopentenyl alcohol) to form the all-trans-retinylidene intermediate. 3. **Reduction**: Reduce the double bond using lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to yield all-trans-retinol. 4. **Purification**: Purify the product via column chromatography or crystallization. Key reagents include β-ionone, Wittig reagents, and reducing agents.

Usage Scenarios: All-trans-Retinol, a form of vitamin A, is primarily used in skincare and dermatology for its anti-aging and skin-rejuvenating properties. It promotes cell turnover, stimulates collagen production, and reduces fine lines, wrinkles, and hyperpigmentation. In cosmetics, it is incorporated into serums, creams, and lotions to improve skin texture and tone. Medically, it treats acne by unclogging pores and regulating sebum production. It also aids in managing psoriasis and other keratinization disorders. In nutritional supplements, it supports vision, immune function, and epithelial tissue health. However, excessive use can cause irritation, requiring careful formulation and usage guidelines.

Vitamin A Basic Info

Chemical Name Vitamin A

Synonyms RETINOL;Vitamin A;Vitamin A1 alcohol;RETINOL (VITAMIN A);Acon;Avita;Afaxin;Alphalin;Del-VI-A;VITAMIN A1

CAS No. 68-26-8

Molecular Formula C20H30O

Molecular Weight 286.45

PSA 20.23000

LogP 5.51030

Safely Info

RTECS VH6750000

Hazard Class -

Safety Statements 36/37-61-62-45-53-16-33-29-9-36/37/39-26

HS Code 29362100

WGK Germany 3

Packing Group -

RIDADR UN 1208 3/PG 2

Risk Statements 22-38-67-65-62-51/53-48/20-11-43-61-63-36/38

Hazard Codes Xn,N,F,T

Caution Statement P201-P273-P280-P302+P352-P305+P351+P338-P308+P313

Hazard Declaration H317-H319-H360FD-H413

Symbol GHS07,GHS08

Signal Word Danger

Vitamin A Price

Here is a rough price range for "all-trans-Retinol" in the 18 countries listed. Note that prices can vary significantly based on purity, quantity, supplier, and market conditions:

1. **United States**: $50 - $200 per gram
2. **China**: $20 - $100 per gram
3. **Russia**: $30 - $150 per gram
4. **Germany**: $50 - $250 per gram
5. **India**: $15 - $80 per gram
6. **Japan**: $60 - $300 per gram
7. **Brazil**: $40 - $180 per gram
8. **South Korea**: $50 - $250 per gram
9. **Philippines**: No results
10. **United Kingdom**: $50 - $250 per gram
11. **France**: $50 - $250 per gram
12. **Mexico**: $30 - $150 per gram
13. **Canada**: $50 - $200 per gram
14. **South Africa**: $40 - $180 per gram
15. **Egypt**: No results
16. **Turkey**: $30 - $150 per gram
17. **Thailand**: $20 - $100 per gram
18. **Indonesia**: No results

*Prices are approximate and may vary depending on the source and market conditions.*

MSDS

Name:	All-Trans-Retinol 95% Material Safety Data Sheet
Synonym:	Vitamin A; Alcon; Afaxin; Avitol; Vitamin A1; Vitamin A Alcoho
CAS:	68-26-8

Section 1 - Chemical Product MSDS Name:All-Trans-Retinol 95% Material Safety Data Sheet
Synonym:Vitamin A; Alcon; Afaxin; Avitol; Vitamin A1; Vitamin A Alcoho

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
68-26-8	all-trans-Retinol	95%	200-683-7

Hazard Symbols: XN
Risk Phrases: 22

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.Light sensitive.Air sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store below 40C.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 68-26-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: yellow
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 120 - 125 deg C @ 760.00mm Hg
Freezing/Melting Point: 61 - 63 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: practically insoluble in water
Specific Gravity/Density:
Molecular Formula: C20H30O
Molecular Weight: 286.45

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, exposure to air, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 68-26-8: VH6750000 LD50/LC50:
CAS# 68-26-8: Oral, mouse: LD50 = 1510 mg/kg; Oral, rat: LD50 = 2 gm/kg.
Carcinogenicity:
all-trans-Retinol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 68-26-8: No information available.
Canada
CAS# 68-26-8 is listed on Canada's DSL List.
CAS# 68-26-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 68-26-8 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

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1.Identification

1.1 GHS Product identifier

Product name	all-trans-Retinol

1.2 Other means of identification

Product number	-
Other names	VITAMIN A

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

Company	MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address	Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China
Telephone	+86(21)64956998
Fax	+86(21)54365166

1.5 Emergency phone number

Emergency phone number	+86-400-6021-666
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Skin sensitization, Category 1

Eye irritation, Category 2

Reproductive toxicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H317 May cause an allergic skin reaction H319 Causes serious eye irritation H360 May damage fertility or the unborn child H413 May cause long lasting harmful effects to aquatic life
Precautionary statement(s)
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
all-trans-Retinol	all-trans-Retinol	68-26-8	none	100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of chronic overdose include fatigue, malaise, lethargy, abdominal discomfort, anorexia and vomiting. Skeletal effects include slow growth, hard tender cortical thickening over the radius and tibia, migratory arthralgia and premature closing of the epiphysis. Central nervous system effects include irritability, headache and increased intracranial pressure as manifested by bulging fontanels, papilledema and exophthalmos. Dermatologic effects include fissures of the lips, drying and cracking of the skin, alopecia, scaling, massive desquamation and increased pigmentation. Systemic effects include hypomenorrhea, hepatosplenomegaly, jaundice, leukopenia and vitamin A plasma level over 1200 units. Other effects include painful nodular periosteal swelling, osteoporosis, itching, skin eruptions, ulcerations, drowsiness, alopecia, liver enlargement, diplopia and papilledema. ACUTE/CHRONIC HAZARDS: When heated to decomposition, this compound emits toxic fumes of carbon monoxide and carbon dioxide. It is harmful if swallowed, inhaled or absorbed through the skin.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Hypervitaminosis A is treated by withdrawing vitamin A and instituting symptomatic and supportive treatment. Some signs and symptoms disappear within 1 week, while others may persist for several weeks to months.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

5.2 Specific hazards arising from the chemical

Flash point data for this chemical are not available. It is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Vitamin A is unstable in, and should be protected from, air and light. Vitamin A preparations should be stored at a temperature less than 40°C, preferably between 15-30°C. Oral vitamin A preparations should be stored in tight, light-resistant containers and the injection should be protected from light and freezing.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state	yellow to orange crystalline solid
Colour	Solvated crystals from polar solvents, such as methanol or ethyl formate
Odour	no data available
Melting point/ freezing point	62-64ºC
Boiling point or initial boiling point and boiling range	137-138
Flammability	no data available
Lower and upper explosion limit / flammability limit	no data available
Flash point	147.3ºC
Auto-ignition temperature	no data available
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	no data available
Solubility	Practically insoluble
Partition coefficient n-octanol/water (log value)	no data available
Vapour pressure	7.35E-09mmHg at 25°C
Density and/or relative density	0.954 g/cm3
Relative vapour density	no data available
Particle characteristics	no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Free alcohol is sensitive to air-oxidation, but oil solutions of it are quite stable; UV light inactivates Vitamin A.

10.3 Possibility of hazardous reactions

VITAMIN A is light sensitive. Also air sensitive and heat sensitive. Reacts with strong oxidizing agents. Also can react with acids . Can react exothermically with reducing agents to release hydrogen gas.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

Oral: LD50 Mouse oral 2570 mg/kg (10 day)
Inhalation: no data available
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown

IMDG: unknown

IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no

IMDG: no

IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
all-trans-Retinol	all-trans-Retinol	68-26-8	none
European Inventory of Existing Commercial Chemical Substances (EINECS)			Listed.
EC Inventory			Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Listed.
China Catalog of Hazardous chemicals 2015			Not Listed.
New Zealand Inventory of Chemicals (NZIoC)			Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Listed.
Vietnam National Chemical Inventory			Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Listed.

16.Other information

Information on revision

Creation Date	Aug 16, 2017
Revision Date	Aug 16, 2017

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

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