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Hydroxyapatite

CAS No.: 1306-06-5
Formula: Ca5HO13P3
Molecular Weight: 502.31
Suppliers: All(0) China Suppliers(0) Products(9)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Price
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What is Hydroxyapatite

**Introduction to Hydroxyapatite** Hydroxyapatite (HA) is a naturally occurring calcium phosphate mineral that forms the primary inorganic component of bones and teeth. Renowned for its biocompatibility and osteoconductive properties, synthetic hydroxyapatite is widely used in medical and dental applications, including bone grafts, dental implants, and coatings for prosthetics. It promotes bone regeneration by integrating seamlessly with natural tissue, reducing rejection risks. In oral care, hydroxyapatite nanoparticles are increasingly popular in toothpaste and mouthwashes for their ability to remineralize enamel, combat cavities, and reduce sensitivity. With its versatility and safety, hydroxyapatite continues to revolutionize regenerative medicine and preventive dentistry, offering effective solutions for bone and dental health.

Preparation Process: Hydroxyapatite (Ca10(PO4)6(OH)2) can be prepared via wet chemical precipitation. Dissolve calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) and diammonium hydrogen phosphate ((NH4)2HPO4) in deionized water separately. Adjust the pH of the phosphate solution to 10–11 using ammonia. Slowly add the calcium solution to the phosphate solution under vigorous stirring at 60–80°C, maintaining the pH. A white precipitate forms, which is aged for 24 hours. The product is filtered, washed with water and ethanol, then dried at 80°C. Alternatively, hydrothermal synthesis or sol-gel methods can be used for higher purity or controlled morphology.

Usage Scenarios: Hydroxyapatite (HA) is a calcium phosphate compound widely used in biomedical and dental applications due to its biocompatibility and similarity to natural bone mineral. In dentistry, it is employed in toothpaste and mouthwash to remineralize enamel, reducing tooth sensitivity and preventing cavities. In orthopedics, HA coatings enhance the osseointegration of implants, promoting bone growth and stability. It serves as a scaffold material in bone tissue engineering, aiding regeneration. Additionally, HA is used in drug delivery systems for controlled release of therapeutics. Its bioactive properties also make it valuable in cosmetic procedures, such as dermal fillers, to improve skin texture and volume.

Hydroxyapatite Basic Info
Chemical Name Hydroxyapatite
Synonyms HA;TRICALCIUM PHOSPHATE;CALCIUM HYDROXYAPATITE;HYDROXYLAPATITE;TRIBASIC CALCIUM PHOSPHATE;Apatite HAP;DURAPATITE;CALCIUM PHOSPHATE HYDROXIDE;BONE ASH;APATITE HAP, MONOCLINIC
CAS No. 1306-06-5
Molecular Formula Ca5HO13P3
Molecular Weight 502.31
PSA 119.12000
LogP 0.20920
Safely Info
RTECS MY8434000
Hazard Class -
Safety Statements 26-36
HS Code 28352600
WGK Germany 3
Packing Group -
RIDADR -
Risk Statements 36/37/38
Hazard Codes Xi
Caution Statement P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Declaration H315-H319-H335
Symbol GHS07
Signal Word Warning
Hydroxyapatite Price
United States: $150 - $300
China: $100 - $250
Russia: $120 - $280
Germany: $200 - $350
India: $80 - $200
Japan: $250 - $400
Brazil: $150 - $300
South Korea: $180 - $320
Philippines: No results
United Kingdom: $180 - $320
France: $200 - $350
Mexico: $120 - $280
Canada: $200 - $350
South Africa: $100 - $250
Egypt: $100 - $250
Turkey: $150 - $300
Thailand: $120 - $280
Indonesia: $80 - $200
MSDS
MSDS
Name: Hydroxylapatite Material Safety Data Sheet
Synonym: Calcium phosphate hydroxide; Durapatit
CAS: 1306-06-5
Section 1 - Chemical Product   MSDS Name:Hydroxylapatite Material Safety Data Sheet
Synonym:Calcium phosphate hydroxide; Durapatit

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1306-06-5 Hydroxylapatite 215-145-7
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
  Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1306-06-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 1700 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: practically insoluble
Specific Gravity/Density:
Molecular Formula: HCa5O13P3
Molecular Weight: 502.31

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Not available.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 1306-06-5: MY8434000 LD50/LC50:
CAS# 1306-06-5: Oral, mouse: LD50 = >99500 mg/kg; Oral, rat: LD50 = >25350 mg/kg.
Carcinogenicity:
Hydroxylapatite - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1306-06-5: 0
Canada
CAS# 1306-06-5 is listed on Canada's DSL List.
CAS# 1306-06-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1306-06-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0
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