1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Dermal, Category 4

Eye irritation, Category 2

Carcinogenicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H312 Harmful in contact with skin H319 Causes serious eye irritation H350 May cause cancer
Precautionary statement(s)
Prevention	P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound may include severe irritation of the skin and eyes, and skin sensitization. It can cause corrosion of tissues. Other symptoms may include burns, irritation of mucous membranes and upper respiratory tract, nausea, vomiting and headaches. Exposure may also cause central nervous system depression, hepatic lesions and pain to the eyes. Symptoms of exposure to a related compound include drying and cracking of the skin on contact, primary irritation to mucosal surfaces, fatigue, weakness, depression, unsteadiness, feeling of drunkenness, abnormal electroencephalograms and one case of toxic retrobulbar neuritis. Chronic exposure to a related compound has caused peripheral neuropathies (distal hypesthesia and decreased nerve conduction velocities). ACUTE/CHRONIC HAZARDS: This compound is corrosive and can cause burns. It may be toxic by ingestion, inhalation or skin absorption. It is absorbed slowly through the skin. It is an irritant and, when heated to decomposition, it emits acrid fumes and toxic fumes of carbon monoxide and carbon dioxide.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aromatic hydrocarbons and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from acids, bases and food and feedstuffs. Ventilation along the floor.... PRECAUTIONS SHOULD BE TAKEN TO PREVENT EXCESSIVE PRESSURE UNDER STORAGE OR REACTION CONDITIONS & TO RELIEVE SUCH PRESSURE SHOULD IT OCCUR.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

On ... basis /of flash point/, it presents hazard of flammability similar to that encountered with ... o-cresol, o-dichlorobenzene, naphthalene, phenol, and dimethylaniline. Definite hazard exists whenever ... /it/ is heated to temperatures at and above the flash point.STYRENE OXIDE is incompatible with oxidizing agents. Also incompatible with acids and bases. Reacts with 4-(4'-nitrobenzyl)pyridine. Polymerizes exothermally and reacts vigorously with compounds possessing a labile hydrogen (e.g. alcohols and amines) in the presence of catalysts such as acids, bases and certain salts .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

REACTS VIGOROUSLY WITH CMPD HAVING LABILE HYDROGEN, INCL WATER, IN PRESENCE OF CATALYSTS SUCH AS ACIDS, BASES, & CERTAIN SALTS

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat oral 3000 mg/kg
• Inhalation: no data available
• Dermal: LD50 Rat percutaneous 930 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence in humans for the carcinogenicity of styrene-7,8-oxide. There is sufficient evidence in experimental animals for the carcinogenicity of styrene-7,8-oxide. Overall evaluation: Styrene-7,8-oxide is probably carcinogenic to humans (Group 2A).

Reproductive toxicity

No information is available on the reproductive or developmental effects of styrene oxide in humans. Maternal toxicity and increased fetal mortality have been observed in rats and rabbits exposed to styrene oxide by inhalation. Maternal toxicity, increased preimplantation loss of fetuses, reduced fetal weight, and increased incidence of ossification defects were reported in rats. Maternal toxicity and increased frequency of resorptions were reported in rabbits.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow, age 30 days, length 17 mm, weight 0.082 g); Conditions: freshwater, flow through, 23.3 (22.5-24.8)°C, pH 6.9 (6.75-7.04), hardness 53.4 mgL CaCO3 (51.9-53.9 mg/L), alkalinity 40.5 mg/L CaCO3 (40-42 mg/L), dissolved oxygen 85.5% (72.9-92.3%); Concentration: 4540 ug/L for 96 hr /97% purity
• Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, age <24 hr neonate); Conditions: freshwater, renewal, 23.7 (23-24.5)°C, pH 8.34 (7.67-8.63), hardness 287.2 mgL CaCO3 (168-437 mg/L), alkalinity 174.2 mg/L CaCO3 (104-261 mg/L), dissolved oxygen 82.6% (75.9-95.3%); Concentration: 11600 ug/L for 48 hr (95% confidence interval: 10200-13100 ug/L) /97% purity
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Styrene-7,8-oxide, present at 100 mg/L, reached 80-82% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1); however, the test results might be for the hydrolysis product, styrene glycol(SRC).

12.3 Bioaccumulative potential

An estimated BCF of 3.5 was calculated in fish for styrene-7,8-oxide(SRC), using a log Kow of 1.61(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolytic half-lives of 0.17, 28 and 40.9 hours have been reported for styrene-7,8-oxide at pH 3, 7, and 9, respectively(4). Hydrolysis is likely to be a more important fate than bioconcentration in aquatic organisms, particularly in acidic waters(SRC).

12.4 Mobility in soil

The Koc of styrene-7,8-oxide is estimated as 53(SRC), using a water solubility of 3,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that styrene-7,8-oxide is expected to have very high mobility in soil. Hydrolytic half-lives of 0.17, 28 and 40.9 hours have been reported for styrene-7,8-oxide at pH 3, 7, and 9, respectively(4). Hydrolysis is likely to be a more important fate than transport through soils, particularly in acidic soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.