ascorbic acid 5-glucoside

What is ascorbic acid 5-glucoside

**Introduction to Ascorbic Acid 5-Glucoside** Ascorbic Acid 5-Glucoside (AA2G) is a stable, water-soluble derivative of vitamin C, formed by bonding ascorbic acid with glucose. This advanced form enhances stability against oxidation, heat, and UV exposure, making it ideal for skincare and cosmetic formulations. Upon application, enzymes in the skin gradually convert AA2G into pure vitamin C, ensuring sustained release and prolonged antioxidant benefits. It brightens skin, reduces hyperpigmentation, and boosts collagen synthesis while minimizing irritation. Widely used in serums, creams, and sunscreens, AA2G offers superior efficacy and shelf life compared to traditional vitamin C, making it a preferred choice for dermatological and anti-aging products.

Preparation Process: Ascorbic acid 5-glucoside is synthesized via enzymatic glycosylation. First, dissolve L-ascorbic acid and a glucosyl donor (e.g., α-D-glucose or starch) in a buffer (pH 5–7). Add a glycosyltransferase enzyme (e.g., cyclodextrin glucanotransferase or sucrose phosphorylase) to catalyze the transfer of the glucosyl unit to the 5-hydroxyl group of ascorbic acid. Incubate the reaction mixture at 30–50°C for 4–24 hours. Monitor the reaction by HPLC. Terminate the reaction by heating or adjusting pH. Purify the product via column chromatography or crystallization. The yield is optimized by controlling substrate ratios, enzyme concentration, and reaction time. The final product is characterized by NMR and mass spectrometry.

Usage Scenarios: Ascorbic acid 5-glucoside is a stable derivative of vitamin C, widely used in cosmetics and skincare for its antioxidant and brightening properties. It inhibits melanin production, reducing hyperpigmentation and promoting an even skin tone. Unlike pure vitamin C, it is less prone to oxidation, ensuring prolonged efficacy in formulations. In pharmaceuticals, it serves as a gentle, long-lasting source of ascorbic acid, supporting collagen synthesis and skin repair. It is also used in food and beverages as a functional additive to enhance nutritional value. Its water-soluble nature and stability make it suitable for serums, creams, and supplements, offering sustained skin benefits and improved bioavailability.

ascorbic acid 5-glucoside Basic Info

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