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FERRITIN, HUMAN

CAS No.: 9007-73-2

Formula: C16H33O2S-

Molecular Weight: 289.49702

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What is FERRITIN, HUMAN

**Introduction to Ferritin, Human** Ferritin, Human, is a crucial iron-storage protein found in nearly all living organisms, playing a vital role in iron metabolism and homeostasis. It consists of a spherical shell that safely sequesters excess iron in a non-toxic, bioavailable form, preventing oxidative damage while ensuring a readily accessible iron reserve for physiological processes. Human ferritin is widely studied for its diagnostic and therapeutic applications, serving as a key biomarker for iron-deficiency anemia, inflammation, and certain cancers. Additionally, its unique nanocage structure makes it an attractive platform for drug delivery, vaccine development, and nanotechnology applications. With high biocompatibility and stability, human ferritin holds significant promise in both medical and biotechnological fields.

Preparation Process: **Preparation Method of Ferritin, Human:** 1. **Source Isolation:** Extract ferritin from human liver or spleen tissues using homogenization in a buffer (e.g., PBS, pH 7.4). 2. **Heat Treatment:** Heat the homogenate at 70–75°C for 10–15 minutes to denature contaminating proteins, then centrifuge to remove precipitates. 3. **Ammonium Sulfate Precipitation:** Fractionate the supernatant with 50% saturated ammonium sulfate, collect the precipitate, and resuspend in buffer. 4. **Ultracentrifugation:** Centrifuge at 100,000–150,000 × g to pellet ferritin, then resuspend in a low-salt buffer. 5. **Gel Filtration/Size Exclusion Chromatography:** Purify further using Sepharose or Sephacryl columns to isolate apoferritin or iron-loaded ferritin. 6. **Dialysis/Storage:** Dialyze against PBS and store at 4°C or –20°C. Iron loading (if needed) involves incubation with ferrous/ferric salts under controlled conditions. (Word count: 100)

Usage Scenarios: Ferritin, human, is a key iron-storage protein that regulates iron homeostasis in the body. It binds and stores excess iron in a non-toxic, soluble form, preventing oxidative damage. Clinically, serum ferritin levels are measured to assess iron deficiency or overload conditions, such as anemia or hemochromatosis. It serves as a biomarker for inflammation and chronic diseases, including liver disorders and certain cancers. Recombinant human ferritin is used in research to study iron metabolism, cellular processes, and nanoparticle applications in drug delivery. Its stable structure also makes it useful in biotechnology for encapsulating and transporting therapeutic agents.

FERRITIN, HUMAN Basic Info

Chemical Name FERRITIN, HUMAN

Synonyms HSF;IFN-b2;ferritins;ferrytyna;IL-6 from rat;Ferritin 26 kDa protein;FERRITIN HORSE;FERRITIN TYPE I;FERRITIN TYPE V

CAS No. 9007-73-2

Molecular Formula C16H33O2S-

Molecular Weight 289.49702

PSA -

LogP -

Safely Info

RTECS LK0500000

Hazard Class -

Safety Statements -

HS Code 35040090

WGK Germany -

Packing Group -

RIDADR UN 3082 9 / PGIII

Risk Statements 22

Hazard Codes B,Xn

Caution Statement P280-P302+P352-P362+P364

Hazard Declaration H315-H319-H335

Symbol GHS07

Signal Word Warning

FERRITIN, HUMAN Price

- **United States**: $50 - $200 per mg
- **China**: $30 - $150 per mg
- **Russia**: $40 - $180 per mg
- **Germany**: $60 - $220 per mg
- **India**: $20 - $100 per mg
- **Japan**: $70 - $250 per mg
- **Brazil**: $35 - $160 per mg
- **South Korea**: $50 - $200 per mg
- **Philippines**: No results
- **United Kingdom**: $60 - $230 per mg
- **France**: $65 - $240 per mg
- **Mexico**: $30 - $150 per mg
- **Canada**: $55 - $210 per mg
- **South Africa**: $25 - $120 per mg
- **Egypt**: No results
- **Turkey**: $40 - $170 per mg
- **Thailand**: $30 - $140 per mg
- **Indonesia**: No results