Titanium Dioxide Acetic Acid Citric Acid Sodium Hydroxide Oxalic Acid Ethyl Acetate

All Categories

Encyclopedia |

Market Inquiry|

Supplier|

About Globalchemx

Hydroxyethyl starch

CAS No.: 9005-27-0

Formula: (C6H10O5)m(C2H5O)n

Molecular Weight: 0

Suppliers: All(0) China Suppliers(6) Products(11)

Description
Basic Info
Safety Info
Price
Related Product
Supplier Reference

What is Hydroxyethyl starch

**Introduction to Hydroxyethyl Starch (HES)** Hydroxyethyl starch (HES) is a synthetic colloid solution derived from natural starch, commonly used as a plasma volume expander in intravenous fluid therapy. It is designed to restore and maintain blood volume in cases of acute hypovolemia, such as during surgery, trauma, or severe hemorrhage. HES works by increasing oncotic pressure, drawing fluid into the bloodstream and improving circulation. Available in various molecular weights and substitution ratios, HES formulations are tailored for different clinical needs. While effective, its use has been debated due to potential risks, including kidney injury and coagulation impairment. Proper patient selection and dosing are essential to maximize benefits and minimize adverse effects.

Preparation Process: Hydroxyethyl starch (HES) is prepared by reacting starch (typically from corn or potatoes) with ethylene oxide under alkaline conditions. The process involves the following steps: 1. **Alkaline Treatment**: Starch is suspended in an alkaline solution (e.g., sodium hydroxide) to activate hydroxyl groups. 2. **Etherification**: Ethylene oxide is introduced, reacting with starch hydroxyl groups to form hydroxyethyl substituents. The degree of substitution (DS) is controlled by reaction time, temperature, and reagent ratios. 3. **Neutralization & Purification**: The product is neutralized, washed, and dried to remove residual reagents. 4. **Fractionation**: HES is hydrolyzed to desired molecular weights (e.g., 130–200 kDa for medical use) and sterilized. The final product is a white, water-soluble powder.

Usage Scenarios: Hydroxyethyl starch (HES) is a synthetic colloid used primarily as a plasma volume expander in intravenous fluid therapy. It helps restore blood volume in cases of acute hypovolemia, such as severe bleeding, surgery, or trauma, by increasing oncotic pressure and retaining fluid within the vascular system. HES solutions are derived from amylopectin and modified with hydroxyethyl groups to prolong their intravascular retention time. They are available in various molecular weights and substitution ratios, influencing their pharmacokinetics. However, HES use has declined due to safety concerns, including risks of kidney injury, coagulopathy, and mortality in critically ill patients, leading to restrictions in some countries.

Hydroxyethyl starch Basic Info

Chemical Name Hydroxyethyl starch

Synonyms hes;RRp;2-hydroxyethyl ether starch;Hydroxyethyl starch (high Mw) CRS;ES130;D03335;ES/130;hespander;essex1360;penford260

CAS No. 9005-27-0

Molecular Formula (C6H10O5)m(C2H5O)n

Molecular Weight 0

PSA -

LogP -

Safely Info

RTECS WI0410000

Hazard Class -

Safety Statements -

HS Code -

WGK Germany -

Packing Group -

RIDADR -

Risk Statements -

Hazard Codes -

Caution Statement -

Hazard Declaration -

Symbol -

Signal Word -

Hydroxyethyl starch Price

Here is a rough price range for Hydroxyethyl Starch (HES) in the listed countries. Note that prices can vary significantly based on factors like product grade, supplier, and market conditions. If no specific data is available, it is marked as "No results":

- **United States**: $50 - $200 per liter
- **China**: $20 - $100 per liter
- **Russia**: $30 - $150 per liter
- **Germany**: $40 - $180 per liter
- **India**: $15 - $80 per liter
- **Japan**: $60 - $250 per liter
- **Brazil**: $25 - $120 per liter
- **South Korea**: $50 - $200 per liter
- **Philippines**: No results
- **United Kingdom**: $45 - $190 per liter
- **France**: $40 - $180 per liter
- **Mexico**: $30 - $130 per liter
- **Canada**: $50 - $200 per liter
- **South Africa**: $20 - $90 per liter
- **Egypt**: No results
- **Turkey**: $25 - $110 per liter
- **Thailand**: $20 - $100 per liter
- **Indonesia**: No results

These ranges are approximate and may not reflect current market conditions. For accurate pricing, consult local suppliers or distributors.