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Hydroxypropyl methyl cellulose

CAS No.: 9004-65-3
Formula: C3H7O*
Molecular Weight: 59.08708
Suppliers: All(0) China Suppliers(47) Products(91)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Synthesis Route
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What is Hydroxypropyl methyl cellulose

**Introduction to Hypromellose** Hypromellose (Hydroxypropyl Methylcellulose, HPMC) is a semisynthetic, inert, and biocompatible polymer widely used in pharmaceuticals, cosmetics, and food industries. As a cellulose derivative, it acts as a thickening, binding, film-forming, and stabilizing agent. In ophthalmic solutions, it lubricates dry eyes, while in oral tablets, it controls drug release. Its water-solubility, pH stability, and non-toxic nature make it ideal for controlled-release formulations, coatings, and as a viscosity modifier. Hypromellose is also used in artificial tears, topical creams, and as a vegetarian capsule alternative to gelatin. Its versatility, safety, and regulatory approval (USP, EP, JP) ensure broad applications in healthcare and industrial products.

Preparation Process: Hypromellose (hydroxypropyl methylcellulose, HPMC) is prepared by treating cellulose with alkali to form alkali cellulose, followed by etherification with methyl chloride and propylene oxide. The process involves: 1. **Alkali Treatment**: Cellulose is soaked in sodium hydroxide solution to produce alkali cellulose. 2. **Etherification**: The alkali cellulose reacts with methyl chloride (for methylation) and propylene oxide (for hydroxypropylation) under controlled temperature and pressure. 3. **Purification**: The crude product is washed with hot water to remove byproducts like sodium chloride and excess reagents. 4. **Drying & Milling**: The purified HPMC is dried and milled to obtain a fine powder with desired viscosity grades. Adjusting reaction conditions controls substitution levels.

Usage Scenarios: Hypromellose (hydroxypropyl methylcellulose, HPMC) is a semisynthetic polymer widely used in pharmaceuticals, cosmetics, and food industries. In pharmaceuticals, it acts as a binder, film-coating agent, and controlled-release matrix in tablets and capsules. It improves viscosity, stabilizes suspensions, and serves as a lubricant in ophthalmic solutions like artificial tears. In food, it functions as a thickener, emulsifier, and stabilizer. Hypromellose is also used in construction materials as a water-retaining agent in cement and gypsum products. Its biocompatibility, non-toxicity, and solubility in water make it a versatile excipient in drug formulations and industrial applications.

Hydroxypropyl methyl cellulose Basic Info
Chemical Name Hydroxypropyl methyl cellulose
Synonyms HPMC;HYPROMELLOSE;MODIFIED CELLULOSE;Hydroxypropyl methyl;METHOCEL E4M;HydroxypropylMethylCellulose(Hpmc);MHPC;cellulose ether HPMC;hydroxylpropylmethylcellulose;Hydroxy propyl methyl collulose
CAS No. 9004-65-3
Molecular Formula C3H7O*
Molecular Weight 59.08708
PSA 0.00000
LogP 0.00000
Safely Info
RTECS NF9125000
Hazard Class -
Safety Statements 24/25
HS Code 39129000
WGK Germany -
Packing Group -
RIDADR -
Risk Statements -
Hazard Codes -
Caution Statement P260-P264-P270-P314-P501
Hazard Declaration H372
Symbol GHS08
Signal Word Danger
Hydroxypropyl methyl cellulose Price
United States: $20-$50
China: $15-$40
Russia: $25-$60
Germany: $30-$70
India: $10-$30
Japan: $40-$80
Brazil: $20-$50
South Korea: $20-$50
Philippines: No results
United Kingdom: $25-$60
France: $30-$70
Mexico: $15-$40
Canada: $25-$60
South Africa: $10-$30
Egypt: $20-$50
Turkey: $20-$50
Thailand: $15-$40
Indonesia: $10-$30
MSDS
MSDS
Name: Hydroxypropyl Methyl Cellulose Material Safety Data Sheet
Synonym: None
CAS: 9004-65-3
Section 1 - Chemical Product   MSDS Name:Hydroxypropyl Methyl Cellulose Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
9004-65-3 Hydroxypropyl Methyl Cellulose ca 100 unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 9004-65-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white to off-white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: chloroform
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 9004-65-3: NF9125000 LD50/LC50:
Not available.
Carcinogenicity:
Hydroxypropyl Methyl Cellulose - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 9004-65-3: 1
Canada
CAS# 9004-65-3 is listed on Canada's DSL List.
CAS# 9004-65-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 9004-65-3 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0
Synthesis Route
Total10 synthetic routes
  • 77-76-9

    2,2-Dimethoxypropane

  • 7216-73-1

    Methyl 4-O-β-D-glucopyranosyl-β-D-glucopyranoside

Reaction details
  • 77-76-9

    2,2-Dimethoxypropane

  • 7216-69-5

    β-D-Gal-(1→4)-β-D-Glc-OMe

Reaction details
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  • 75-50-3

    trimethylamine

  • 7446-11-9

    sulfur trioxide

  • 7216-73-1

    Methyl 4-O-β-D-glucopyranosyl-β-D-glucopyranoside

  • 75-50-3

    trimethylamine

  • None

Reaction details
  • 57-55-6

    1,2-Propanediol

  • 35320-23-1

    (R)-(-)-2-Amino-1-propanol

  • 4254-15-3

    (S)-(+)-1,2-Propanediol

Reaction details
  • 97-64-3

    Ethyl lactate

  • 4254-14-2

    (R)-propane-1,2-diol

  • 26264-14-2

Reaction details
  • 67-56-1

    Methanol

  • 71750-61-3

    Strontium 4-[(E)-(3-chloro-4-methyl-5-sulfophenyl)diazenyl]-3-oxi do-2-naphthoate

  • 14797-55-8

    Nitrate

  • 14701-21-4

    silver(1+)

Reaction details
  • 60782-58-3

    trihexyl(hydroxy)silane

  • 67-56-1

    Methanol

  • 22537-24-2

  • None

  • 22537-24-2

Reaction details
  • 68188-03-4

  • 13517-11-8

    hypobromous acid

  • 14519-10-9

    Bromamine

Reaction details
  • 67-56-1

    Methanol

  • 672-13-9

    2-Hydroxy-5-methoxybenzaldehyde

  • 78-96-6

    1-aminopropan-2-ol

Reaction details
  • 17361-58-9

    4-methyl-1,3-dioxan-2-one

  • 67-56-1

    Methanol

  • 107-88-0

    butane-1,3-diol

Reaction details
  • 1
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China Hebei Shijiazhuang
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China Shanghai Fengxian
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China Hubei Wuhan
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China Zhejiang Huzhou
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