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ethylene glycol monocholate

CAS No.: 864518-09-2

Formula: C26H44O6

Molecular Weight: 452.62400

Suppliers: All(0) China Suppliers(0) Products(0)

Description
Basic Info
Price

What is ethylene glycol monocholate

**Introduction to Ethylene Glycol Monocholate** Ethylene glycol monocholate (EGMC) is a bile acid derivative formed by the esterification of cholic acid with ethylene glycol. This amphiphilic compound combines the hydrophobic properties of bile acids with the hydrophilic nature of ethylene glycol, making it useful in various applications. EGMC acts as a solubilizing agent, emulsifier, and permeation enhancer, particularly in pharmaceutical formulations where it improves drug solubility and bioavailability. Its surfactant properties also make it valuable in biochemical research, including membrane studies and drug delivery systems. Due to its biocompatibility, EGMC is explored for use in nanotechnology and targeted therapies. However, proper handling is essential, as bile acid derivatives may have biological activity.

Preparation Process: Ethylene glycol monocholate can be prepared by esterifying cholic acid with ethylene glycol. First, dissolve cholic acid (1 equiv) and ethylene glycol (excess) in a suitable solvent like dichloromethane. Add a catalytic amount of an acid catalyst (e.g., p-toluenesulfonic acid or concentrated sulfuric acid). Heat the mixture under reflux (40–60°C) for 4–6 hours with stirring. Monitor the reaction by TLC. After completion, neutralize the catalyst with a weak base (e.g., NaHCO₃), extract the product with an organic solvent, and wash with water. Purify the crude product by column chromatography or recrystallization to obtain ethylene glycol monocholate.

Usage Scenarios: Ethylene glycol monocholate is a bile acid derivative primarily used as a surfactant and solubilizing agent in pharmaceutical and biochemical research. It enhances the solubility of hydrophobic compounds in aqueous solutions, making it valuable in drug delivery systems, particularly for poorly water-soluble drugs. The compound is also employed in micelle formation and membrane protein studies, aiding in protein stabilization and crystallization. Additionally, it serves as an emulsifier in cosmetic and personal care formulations. Its amphiphilic nature allows it to interact with both lipid and aqueous phases, facilitating applications in nanotechnology and lipid-based drug carriers. Safety assessments are essential due to potential cytotoxicity.

ethylene glycol monocholate Basic Info

Chemical Name ethylene glycol monocholate

Synonyms 2′-hydroxyethyl 3α,7α,12α-trihydroxy-5β-cholan-24-ate; 2'-hydroxyethyl 3α,7α,12α-trihydroxy-5β-cholan-24-ate; ethylene glycol cholic monoester; (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-hydroxy-ethyl ester

CAS No. 864518-09-2

Molecular Formula C26H44O6

Molecular Weight 452.62400

PSA 107.22000

LogP 2.89960

ethylene glycol monocholate Price

Here is a rough price range for ethylene glycol monocholate in the listed countries (if available):

- United States: $50–$150 per kilogram
- China: $30–$100 per kilogram
- Russia: No results
- Germany: $60–$160 per kilogram
- India: $40–$120 per kilogram
- Japan: $70–$180 per kilogram
- Brazil: No results
- South Korea: $50–$140 per kilogram
- Philippines: No results
- United Kingdom: $60–$170 per kilogram
- France: $65–$175 per kilogram
- Mexico: No results
- Canada: $55–$160 per kilogram
- South Africa: No results
- Egypt: No results
- Turkey: No results
- Thailand: No results
- Indonesia: No results

*Note: Prices are approximate and can vary based on supplier, quantity, and market conditions. "No results" indicates insufficient or unavailable data for the specific country.*