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all-cis-retinol

CAS No.: 85354-10-5

Formula: C20H30O

Molecular Weight: 286.45200

Suppliers: All(0) China Suppliers(0) Products(0)

Description
Basic Info
Price

What is all-cis-retinol

**Introduction to All-*cis*-Retinol** All-*cis*-retinol is a highly bioactive form of vitamin A, renowned for its pivotal role in skin health and cellular regeneration. As the natural *cis*-isomer of retinol, it offers superior stability and efficacy compared to synthetic alternatives, making it a preferred ingredient in advanced dermatological and cosmetic formulations. Its molecular structure allows for optimal binding to cellular retinol receptors, enhancing collagen synthesis, reducing fine lines, and improving skin texture. Additionally, all-*cis*-retinol supports vision, immune function, and epithelial tissue maintenance. With its proven anti-aging and therapeutic benefits, this compound is widely utilized in skincare serums, creams, and medical treatments, delivering visible results with minimal irritation. Ideal for both professional and consumer use, all-*cis*-retinol remains a gold standard in retinoid-based care. (100 words)

Preparation Process: To prepare all-cis-retinol, begin with β-ionone as the starting material. Convert β-ionone to β-C15 aldehyde via Grignard reaction with vinylmagnesium bromide, followed by oxidation. Perform a Wittig reaction with a C5 phosphonium salt (triphenylphosphonium ylide) to extend the chain and introduce the polyene system, yielding all-trans-retinyl acetate. Isomerize the all-trans product to all-cis-retinol using iodine or light under controlled conditions. Purify the product via column chromatography. Protect sensitive groups during synthesis to prevent oxidation. Confirm the structure using NMR and HPLC. Store under inert gas to avoid degradation.

Usage Scenarios: All-cis-retinol, a form of vitamin A, is primarily used in vision health, cellular growth, and immune function. It plays a critical role in the visual cycle by converting to retinaldehyde, a component of rhodopsin in photoreceptor cells. Additionally, it supports epithelial tissue maintenance, skin health, and mucous membrane integrity. In dermatology, all-cis-retinol is used in anti-aging and acne treatments due to its ability to promote cell turnover and collagen production. It also aids in immune regulation by enhancing white blood cell activity. Dietary supplements and topical formulations often include all-cis-retinol to address deficiencies or improve skin conditions.

all-cis-retinol Basic Info

Chemical Name all-cis-retinol

Synonyms (2Z,4Z,6Z,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraen-1-ol

CAS No. 85354-10-5

Molecular Formula C20H30O

Molecular Weight 286.45200

PSA 20.23000

LogP 5.51030

all-cis-retinol Price

Here is a rough price range for the chemical product "all-cis-retinol" in the 18 countries listed. Note that these ranges are approximate and may vary based on suppliers, purity, and market conditions:

- **United States**: $100–$500 per gram
- **China**: $50–$300 per gram
- **Russia**: $80–$400 per gram
- **Germany**: $120–$600 per gram
- **India**: $60–$350 per gram
- **Japan**: $150–$700 per gram
- **Brazil**: $100–$450 per gram
- **South Korea**: $130–$550 per gram
- **Philippines**: No results
- **United Kingdom**: $110–$500 per gram
- **France**: $120–$600 per gram
- **Mexico**: $90–$400 per gram
- **Canada**: $100–$500 per gram
- **South Africa**: $70–$350 per gram
- **Egypt**: No results
- **Turkey**: $80–$400 per gram
- **Thailand**: $70–$300 per gram
- **Indonesia**: No results

These ranges are based on general market trends and may not reflect exact prices. Availability and pricing can vary significantly depending on the supplier and specific market conditions.