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diglycyl-histidine

CAS No.: 7451-76-5
Formula: C10H15N5O4
Molecular Weight: 269.26
Suppliers: All(0) China Suppliers(0) Products(0)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Price
What is diglycyl-histidine

Diglycyl-histidine is a synthetic tripeptide composed of two glycine residues and one histidine residue, known for its potential applications in skincare, anti-aging, and biomedical research. This peptide is valued for its antioxidant properties, which help neutralize free radicals and protect cells from oxidative stress, a key factor in aging and cellular damage. Additionally, diglycyl-histidine has been studied for its ability to support collagen synthesis, promoting skin elasticity and reducing the appearance of fine lines and wrinkles. Its biocompatibility and stability make it a promising ingredient in cosmetic formulations and therapeutic agents. With ongoing research, diglycyl-histidine continues to gain attention for its versatile benefits in health and beauty industries.

Preparation Process: To prepare diglycyl-histidine, follow these steps: 1. **Protection**: Protect the amino group of glycine (Gly) with Boc (tert-butoxycarbonyl) and the carboxyl group of histidine (His) with a benzyl ester. 2. **Coupling**: Activate Boc-Gly-OH with DCC (dicyclohexylcarbodiimide) and HOBt (hydroxybenzotriazole), then couple it with H-His-OBzl to form Boc-Gly-His-OBzl. 3. **Deprotection**: Remove the Boc group using TFA (trifluoroacetic acid). 4. **Second Coupling**: Repeat the coupling step with another Boc-Gly-OH, then deprotect again to yield H-Gly-Gly-His-OH. 5. **Final Deprotection**: Hydrogenate to remove the benzyl ester, yielding diglycyl-histidine. Purify by HPLC or recrystallization. (100 words)

Usage Scenarios: Diglycyl-histidine, a tripeptide composed of two glycine residues and one histidine, serves various applications in biochemical and medical research. It acts as a substrate for studying enzyme activity, particularly proteases and peptidases, due to its peptide bonds. The compound is also used in investigations of metal ion chelation, leveraging histidine's imidazole group to bind metals like copper and zinc, relevant in neurodegenerative disease research. Additionally, diglycyl-histidine aids in peptide synthesis and protein engineering. Its antioxidant properties make it valuable in oxidative stress studies, while its role in wound healing and tissue repair is explored in dermatological and regenerative medicine research.

diglycyl-histidine Basic Info
Chemical Name diglycyl-histidine
Synonyms GGH;Nsc 334195;diglycyl-histidine;Rabbit Anti-GGH antibody;L-Histidine,glycylglycyl-;N-(N-Glycylglycyl)histidine;diglycyl-histidine USP/EP/BP;L-Histidine, N-(N-glycylglycyl)-;2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoicaci;2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
CAS No. 7451-76-5
Molecular Formula C10H15N5O4
Molecular Weight 269.26
PSA 150.20000
LogP -0.92140
Safely Info
RTECS -
Hazard Class -
Safety Statements -
HS Code -
WGK Germany -
Packing Group -
RIDADR -
Risk Statements -
Hazard Codes -
Caution Statement -
Hazard Declaration -
Symbol -
Signal Word -
diglycyl-histidine Price
Here is a rough price range for the chemical product "diglycyl-histidine" in the 18 countries listed. Note that prices can vary significantly based on suppliers, purity, and market conditions. If no specific data is available, it is marked as "No results":

- **United States**: $50 - $200 per gram
- **China**: $20 - $100 per gram
- **Russia**: No results
- **Germany**: $60 - $250 per gram
- **India**: $30 - $150 per gram
- **Japan**: $70 - $300 per gram
- **Brazil**: No results
- **South Korea**: $50 - $200 per gram
- **Philippines**: No results
- **United Kingdom**: $60 - $250 per gram
- **France**: $70 - $300 per gram
- **Mexico**: No results
- **Canada**: $50 - $200 per gram
- **South Africa**: No results
- **Egypt**: No results
- **Turkey**: No results
- **Thailand**: No results
- **Indonesia**: No results

*Prices are approximate and may vary based on supplier, quantity, and purity.*
MSDS
MSDS

Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
  Product identifiers
    Product name        : GLY-GLY-HIS    
    CAS-No.        : 7451-76-5    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

Section 2. HAZARDS IDENTIFICATION
  Classification of the substance or mixture
    Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
    This substance is not classified as dangerous according to Directive 67/548/EEC.
  Label elements
    The product does not need to be labelled in accordance with EC directives or respective national laws.
  Other hazards - none

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Substances
    Synonyms        : NSC 334195    
    N-(N-Glycylglycyl)histidine
    Glycylglycyl-L-histidine
    diglycyl-L-histidine
    Formula        : C10H15N5O4    
    Molecular Weight        : 269,26 g/mol    

Section 4. FIRST AID MEASURES
  Description of first aid measures
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration.
  In case of skin contact
    Wash off with soap and plenty of water.
  In case of eye contact
    Flush eyes with water as a precaution.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water.
  Most important symptoms and effects, both acute and delayed
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.
  Indication of any immediate medical attention and special treatment needed
    no data available

Section 5. FIREFIGHTING MEASURES
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx)
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

Section 6. ACCIDENTAL RELEASE MEASURES
  Personal precautions, protective equipment and emergency procedures
    Avoid dust formation. Avoid breathing vapors, mist or gas.
  Environmental precautions
    Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Sweep up and shovel. Keep in suitable, closed containers for disposal.
  Reference to other sections
    For disposal see section 13.

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
    Provide appropriate exhaust ventilation at places where dust is formed.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Recommended storage temperature: -20 °C
  Specific end uses
    no data available

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    General industrial hygiene practice.
  Personal protective equipment
  Eye/face protection
    Use equipment for eye protection tested and approved under appropriate government standards
    such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Choose body protection in relation to its type, to the concentration and amount of dangerous
    substances, and to the specific work-place., The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
    use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
    approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Information on basic physical and chemical properties
    a) Appearance        Form: solid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evaporation rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        no data available    
    n) Water solubility        50 g/l - soluble    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Autoignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

Section 10. STABILITY AND REACTIVITY
  Reactivity
    no data available
  Chemical stability
    no data available
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    no data available
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available

Section 11. TOXICOLOGICAL INFORMATION
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitization
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Potential health effects
  Inhalation        May be harmful if inhaled. May cause respiratory tract irritation.    
  Ingestion        May be harmful if swallowed.    
  Skin        May be harmful if absorbed through skin. May cause skin irritation.    
  Eyes        May cause eye irritation.    
  Signs and Symptoms of Exposure
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.
  Additional Information
    RTECS: Not available

Section 12. ECOLOGICAL INFORMATION
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    no data available
  Other adverse effects
    no data available

Section 13. DISPOSAL CONSIDERATIONS
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

Section 14. TRANSPORT INFORMATION
  UN number
    ADR/RID: -        IMDG: -        IATA: -    
  UN proper shipping name
    ADR/RID: Not dangerous goods
    IMDG: Not dangerous goods
    IATA:        Not dangerous goods    
  Transport hazard class(es)
    ADR/RID: -        IMDG: -        IATA: -    
  Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0