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Human serum albumin

CAS No.: 70024-90-7

Formula: -

Molecular Weight: 0

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What is Human serum albumin

**Introduction to Human Serum Albumin (HSA)** Human Serum Albumin (HSA) is a vital plasma protein produced by the liver, constituting about 50% of total blood plasma protein. Known for its exceptional binding and transport capabilities, HSA plays a crucial role in maintaining osmotic pressure, transporting hormones, fatty acids, and drugs, and stabilizing fluid balance. Its biocompatibility, biodegradability, and non-immunogenicity make it widely used in therapeutic applications, including shock treatment, burns, liver cirrhosis, and hypoalbuminemia. Additionally, HSA serves as an excipient in drug formulations and a stabilizer in vaccines and biologics. With its multifunctional properties, HSA remains indispensable in both clinical medicine and biotechnological research.

Preparation Process: Human serum albumin (HSA) is typically isolated from human plasma through fractionation. The **Cohn process** (cold ethanol fractionation) is commonly used: 1. **Plasma Collection**: Blood is centrifuged to separate plasma from cellular components. 2. **Precipitation**: Plasma is mixed with ethanol at low temperature (pH 5.8) to precipitate impurities. 3. **Fractionation**: Albumin-rich fractions (Fraction V) are separated via centrifugation. 4. **Purification**: Further purification involves ion-exchange chromatography or ultrafiltration to remove residual contaminants. 5. **Stabilization**: The purified albumin is pasteurized (60°C for 10 hours) and formulated with stabilizers (e.g., sodium caprylate). 6. **Sterilization**: Final product is filtered and aseptically filled into vials. Recombinant HSA can also be produced using yeast or bacterial expression systems.

Usage Scenarios: Human serum albumin (HSA) is a plasma protein widely used in medical and biotechnological applications. Clinically, it serves as a volume expander to treat hypovolemia, shock, and burns by maintaining oncotic pressure and stabilizing blood circulation. It is also used in surgeries and trauma care. In drug delivery, HSA acts as a carrier for therapeutic agents, enhancing solubility and targeting. Biotechnologically, it stabilizes labile compounds, supports cell culture media, and serves as a blocking agent in immunoassays. Additionally, HSA is utilized in diagnostic kits and vaccine formulations. Its biocompatibility and non-immunogenicity make it valuable in therapeutic and research settings.

Human serum albumin Basic Info

Chemical Name Human serum albumin

Synonyms HSA;RSA;HUMAN ALBUMIN;rHSA;ALBUMIN, HUMAN;Alburx;Albagen;albucult;Flexbumin;Cellastim

CAS No. 70024-90-7

Molecular Formula -

Molecular Weight 0

PSA -

LogP -

Safely Info

RTECS -

Hazard Class -

Safety Statements 23-24/25-36/37

HS Code 35029000

WGK Germany -

Packing Group -

RIDADR -

Risk Statements 21/22

Hazard Codes B,Xn

Caution Statement P261-P271-P280

Hazard Declaration H315-H319-H335

Symbol GHS07

Signal Word Warning

Human serum albumin Price

Here is a rough price range for Human Serum Albumin (HSA) in the listed countries. Note that prices can vary based on factors like brand, concentration, and local market conditions:

1. **United States**: $500 - $1,500 per 50 mL vial
2. **China**: $300 - $800 per 50 mL vial
3. **Russia**: $400 - $900 per 50 mL vial
4. **Germany**: $600 - $1,200 per 50 mL vial
5. **India**: $200 - $600 per 50 mL vial
6. **Japan**: $700 - $1,500 per 50 mL vial
7. **Brazil**: $400 - $900 per 50 mL vial
8. **South Korea**: $500 - $1,000 per 50 mL vial
9. **Philippines**: $300 - $700 per 50 mL vial
10. **United Kingdom**: $600 - $1,300 per 50 mL vial
11. **France**: $600 - $1,200 per 50 mL vial
12. **Mexico**: $400 - $900 per 50 mL vial
13. **Canada**: $500 - $1,200 per 50 mL vial
14. **South Africa**: $300 - $800 per 50 mL vial
15. **Egypt**: $200 - $600 per 50 mL vial
16. **Turkey**: $300 - $700 per 50 mL vial
17. **Thailand**: $200 - $600 per 50 mL vial
18. **Indonesia**: $200 - $600 per 50 mL vial

If no specific data is available for a country, it is marked as "No results." Prices are approximate and may vary.