CSRNLIDC (disulfide bond: 1-8)

What is CSRNLIDC (disulfide bond: 1-8)

**Introduction to CSRNLIDC (Disulfide Bond: 1-8)** CSRNLIDC is a synthetic cyclic peptide featuring a disulfide bond between cysteine residues at positions 1 and 8, enhancing its structural stability and biological activity. This constrained conformation improves receptor binding affinity and resistance to enzymatic degradation, making it a promising candidate for therapeutic and research applications. The peptide’s unique sequence and cyclization are designed to mimic natural bioactive peptides, potentially targeting specific pathways involved in cell signaling, inflammation, or antimicrobial activity. CSRNLIDC’s well-defined structure and stability under physiological conditions make it suitable for drug development, biochemical studies, and as a molecular tool for investigating disulfide-rich peptide interactions. Its versatility underscores its potential in biomedical innovation. (Approx. 100 words)

Preparation Process: To prepare the compound CSRNLIDC (disulfide bond: 1-8), follow these steps: 1. **Solid-Phase Peptide Synthesis (SPPS)**: Use Fmoc chemistry to assemble the linear peptide (Cys1-Ser-Arg-Asn-Leu-Ile-Asp-Cys8) on a resin. 2. **Selective Deprotection**: Cleave the side-chain protecting groups while keeping the Cys thiols protected (e.g., with Trt or Acm). 3. **Cleavage and Deprotection**: Release the peptide from the resin using TFA and scavengers, then deprotect the Cys residues. 4. **Oxidative Folding**: Dissolve the peptide in a buffered solution (pH 7–8, with 0.1–1 mM GSH/GSSG) to form the 1-8 disulfide bond. 5. **Purification**: Isolate the cyclized peptide via RP-HPLC and confirm by MS.

Usage Scenarios: CSRNLIDC (disulfide bond: 1-8) is a cyclic peptide with potential applications in drug development due to its constrained structure, enhancing stability and binding affinity. Its disulfide bridge (Cys1-Cys8) improves resistance to enzymatic degradation, making it suitable for therapeutic use. The peptide may act as a modulator of protein-protein interactions, particularly in targeting receptors or enzymes involved in diseases like cancer or inflammation. Its cyclic nature allows for selective binding to biological targets, enabling precise therapeutic interventions. Additionally, CSRNLIDC could serve as a scaffold for peptide-based drug design, facilitating the development of novel bioactive compounds with improved pharmacokinetic properties. Research explores its role in antimicrobial or antiviral therapies.

CSRNLIDC (disulfide bond: 1-8) Basic Info

CSRNLIDC (disulfide bond: 1-8) Price