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Ibuprofen Piconol

CAS No.: 64622-45-3

Formula: C19H23NO2

Molecular Weight: 297.4

Suppliers: All(0) China Suppliers(3) Products(3)

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What is Ibuprofen Piconol

**Introduction to Ibuprofen Piconol** Ibuprofen Piconol is a topical nonsteroidal anti-inflammatory drug (NSAID) that combines the anti-inflammatory and analgesic properties of ibuprofen with enhanced skin absorption. Designed for localized pain relief, it effectively targets muscle aches, joint discomfort, and inflammation without the gastrointestinal side effects often associated with oral NSAIDs. The piconol ester formulation improves transdermal delivery, ensuring deeper tissue penetration for faster and more efficient relief. Ideal for conditions like arthritis, sprains, and strains, Ibuprofen Piconol offers a convenient, non-invasive alternative to oral medications. Its targeted action minimizes systemic exposure while maximizing therapeutic benefits, making it a preferred choice for managing localized pain and inflammation.

Preparation Process: To prepare Ibuprofen Piconol, follow these steps: 1. **Esterification**: React ibuprofen (2-(4-isobutylphenyl)propionic acid) with picolyl alcohol (2-pyridinemethanol) in the presence of a coupling agent like DCC (dicyclohexylcarbodiimide) and a catalyst such as DMAP (4-dimethylaminopyridine) in anhydrous dichloromethane. 2. **Purification**: After stirring at room temperature for 12–24 hours, filter the reaction mixture to remove dicyclohexylurea (DCU) byproduct. 3. **Isolation**: Concentrate the filtrate under reduced pressure and purify the crude product via column chromatography (silica gel, ethyl acetate/hexane eluent). 4. **Characterization**: Confirm the structure using NMR and mass spectrometry. Yield typically ranges from 70–85%.

Usage Scenarios: Ibuprofen Piconol is a topical nonsteroidal anti-inflammatory drug (NSAID) derived from ibuprofen. It is primarily used to relieve localized pain, inflammation, and swelling associated with musculoskeletal conditions, such as sprains, strains, and arthritis. The compound penetrates the skin to inhibit prostaglandin synthesis, reducing pain and inflammation at the application site. Its piconol ester form enhances skin absorption, improving efficacy. Common applications include treating joint pain, muscle soreness, and minor sports injuries. Unlike oral NSAIDs, it minimizes systemic side effects like gastrointestinal irritation. It is available in creams, gels, or patches for targeted relief.

Ibuprofen Piconol Basic Info

Chemical Name Ibuprofen Piconol

Synonyms BO-36;BE 100;Vesicum;U 75630;Staderm;Pimeprofen;Pimeprophen;Ibuprofenpiconol;Einecs 264-979-8;Cymoxanil Impurity 2

CAS No. 64622-45-3

Molecular Formula C19H23NO2

Molecular Weight 297.4

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Ibuprofen Piconol Price

Here is a rough price range for the chemical product "Ibuprofen Piconol" in the 18 countries listed. Note that prices can vary significantly based on suppliers, quantities, and market conditions. If no specific data is available, it is marked as "No results":

1. **United States**: $50 - $150 per kilogram
2. **China**: $20 - $80 per kilogram
3. **Russia**: $30 - $100 per kilogram
4. **Germany**: $60 - $160 per kilogram
5. **India**: $25 - $90 per kilogram
6. **Japan**: $70 - $180 per kilogram
7. **Brazil**: $40 - $120 per kilogram
8. **South Korea**: $50 - $140 per kilogram
9. **Philippines**: No results
10. **United Kingdom**: $60 - $170 per kilogram
11. **France**: $65 - $175 per kilogram
12. **Mexico**: $35 - $110 per kilogram
13. **Canada**: $55 - $160 per kilogram
14. **South Africa**: $30 - $100 per kilogram
15. **Egypt**: No results
16. **Turkey**: $40 - $120 per kilogram
17. **Thailand**: No results
18. **Indonesia**: No results

These ranges are approximate and may vary depending on market conditions, supplier pricing, and other factors.