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Insulin-like growth factor

CAS No.: 61912-98-9

Formula: -

Molecular Weight: 0

Suppliers: All(0) China Suppliers(0) Products(0)

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What is Insulin-like growth factor

**Introduction to Insulin-like Growth Factor (IGF)** Insulin-like Growth Factor (IGF) is a naturally occurring hormone that plays a crucial role in growth, development, and cellular repair. Structurally similar to insulin, IGF exists in two primary forms—IGF-1 and IGF-2—with IGF-1 being the most biologically active. It mediates the effects of growth hormone (GH), promoting cell proliferation, tissue regeneration, and muscle growth. IGF is essential for childhood development and maintains metabolic functions in adults. Clinically, it is studied for its potential in treating growth disorders, diabetes, and muscle-wasting diseases. However, its misuse as a performance-enhancing drug raises ethical and health concerns. Research continues to explore its therapeutic applications while balancing safety.

Preparation Process: Insulin-like growth factor (IGF) can be prepared via recombinant DNA technology. The gene encoding IGF is inserted into a plasmid vector, which is then transfected into host cells like *E. coli* or mammalian cells (e.g., CHO cells). The cells are cultured in a bioreactor under controlled conditions to express the protein. Post-expression, the cells are lysed, and IGF is purified using chromatography techniques such as affinity, ion-exchange, and size-exclusion chromatography. The purified protein is then refolded if necessary, concentrated, and sterilized. Quality control tests (e.g., SDS-PAGE, HPLC, bioassays) ensure purity and bioactivity.

Usage Scenarios: Insulin-like growth factor (IGF) is primarily used to promote cell growth and proliferation, playing a key role in development and tissue repair. It is utilized in medical treatments for growth disorders, such as growth hormone insensitivity syndrome (GHIS) and short stature. IGF also aids in muscle recovery and is studied for potential applications in muscle-wasting conditions like sarcopenia and certain cancers. In sports medicine, it is explored for enhancing muscle regeneration post-injury, though its use is controversial due to doping concerns. Additionally, IGF is researched in wound healing, diabetes management, and neurodegenerative diseases due to its neuroprotective effects.

Insulin-like growth factor Basic Info

Chemical Name Insulin-like growth factor

Synonyms IGF;IGF-I;IGFIA;Somatamedin C;IGF-I from rat;LONG(TM) R3 IGF-1;HUMAN LONG R3IGF-I;Insulin-like growth factor;INSULIN-LIKE GROWTH FACTOR-I HUMAN

CAS No. 61912-98-9

Molecular Formula -

Molecular Weight 0

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Insulin-like growth factor Price

Here is a rough price range for Insulin-like Growth Factor (IGF) in the listed countries. Note that prices can vary significantly based on factors like purity, source, and intended use (research, medical, etc.). If no specific data is available, "No results" is indicated:

- **United States**: $200 - $1,000 per mg
- **China**: $100 - $500 per mg
- **Russia**: $150 - $600 per mg
- **Germany**: $250 - $1,200 per mg
- **India**: $80 - $400 per mg
- **Japan**: $300 - $1,500 per mg
- **Brazil**: $200 - $800 per mg
- **South Korea**: $250 - $1,000 per mg
- **Philippines**: No results
- **United Kingdom**: $300 - $1,200 per mg
- **France**: $250 - $1,100 per mg
- **Mexico**: $150 - $700 per mg
- **Canada**: $200 - $1,000 per mg
- **South Africa**: No results
- **Egypt**: No results
- **Turkey**: $100 - $500 per mg
- **Thailand**: No results
- **Indonesia**: No results

These ranges are approximate and may vary depending on suppliers, regulations, and market conditions. For precise pricing, consult local suppliers or distributors.