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        H-THR-NH2 HCL

        CAS No.: 33209-01-7
        Formula: C4H11ClN2O2
        Molecular Weight: 154.59
        Suppliers: All(0) China Suppliers(0) Products(0)
        • Description
        • Basic Info
        • Safety Info
        • MSDS
        • Price
        • Supplier Reference
        What is H-THR-NH2 HCL

        **Introduction to H-THR-NH2 HCl** H-THR-NH2 HCl is a high-purity synthetic peptide derivative, commonly used in pharmaceutical research, biochemical studies, and drug development. This compound features a threonine (Thr) residue with an amine-terminated modification, stabilized in its hydrochloride (HCl) salt form for enhanced solubility and stability. It serves as a key intermediate in peptide synthesis, enabling the construction of complex bioactive molecules. Due to its structural versatility, H-THR-NH2 HCl is valuable in exploring enzyme-substrate interactions, receptor binding studies, and therapeutic peptide design. Rigorously tested for quality, it ensures reliable performance in laboratory applications. Ideal for researchers, this product supports advancements in proteomics, medicinal chemistry, and bioconjugation technologies.

        Preparation Process: To prepare H-Thr-NH2·HCl, follow these steps: 1. **Dissolve H-Thr-OH (1.0 equiv.)** in anhydrous DMF under nitrogen. 2. **Add HATU (1.1 equiv.) and DIPEA (2.0 equiv.)**, stir for 5 min. 3. **Introduce NH4Cl (1.5 equiv.)**, react at RT for 4–6 h. 4. **Quench with water**, extract with ethyl acetate, and dry (Na2SO4). 5. **Concentrate under vacuum** to obtain crude H-Thr-NH2. 6. **Dissolve in HCl/dioxane (4M, 1.1 equiv.)**, stir for 30 min. 7. **Precipitate with cold ether**, filter, and wash with ether. 8. **Dry under vacuum** to yield H-Thr-NH2·HCl as a white solid. (100 words)

        Usage Scenarios: H-Thr-NH2 HCl, or L-threoninamide hydrochloride, is a protected amino acid derivative used in peptide synthesis and pharmaceutical research. It serves as a building block for constructing peptides with specific sequences, particularly where threonine residues are required. The compound is employed in solid-phase peptide synthesis (SPPS) and solution-phase methods to enhance solubility and stability during reactions. It also finds applications in biochemical studies, enzyme substrate research, and drug development. The hydrochloride salt form improves handling and storage. Additionally, H-Thr-NH2 HCl is utilized in the study of protein-protein interactions, metabolic pathways, and as a precursor for modified amino acids or peptidomimetics.

        H-THR-NH2 HCL Basic Info
        Chemical Name H-THR-NH2 HCL
        Synonyms THR-NH2HCL;L-Thr-NH2·HCl;H-THR-NH2·HCL;H-THR-NH2 HCL;H-L-THR-NH2 HCL;THREONINE-NH2 HCL;L-ThreonineamideHCl;L-Threoninamide HCl;H-Thr-Nh2 Hydrochloride;TIANFU CHEM--H-THR-NH2 HCL
        CAS No. 33209-01-7
        Molecular Formula C4H11ClN2O2
        Molecular Weight 154.59
        PSA 89.34000
        LogP 0.38240
        Safely Info
        RTECS -
        Hazard Class -
        Safety Statements -
        HS Code 2924199090
        WGK Germany -
        Packing Group -
        RIDADR -
        Risk Statements -
        Hazard Codes -
        Caution Statement P261-P280-P305+P351+P338-P304+P340-P405-P501
        Hazard Declaration H302-H312-H315-H319-H331-H335
        Symbol GHS06
        Signal Word Danger
        H-THR-NH2 HCL Price
        Here is a rough price range for the chemical product "H-THR-NH2 HCL" in the 18 countries listed. Note that these are approximate ranges and may vary based on suppliers, market conditions, and other factors:

        - **United States**: $50 - $200 per gram
        - **China**: $20 - $100 per gram
        - **Russia**: $30 - $150 per gram
        - **Germany**: $50 - $250 per gram
        - **India**: $10 - $80 per gram
        - **Japan**: $60 - $300 per gram
        - **Brazil**: $40 - $180 per gram
        - **South Korea**: $50 - $250 per gram
        - **Philippines**: No results
        - **United Kingdom**: $50 - $250 per gram
        - **France**: $50 - $250 per gram
        - **Mexico**: $30 - $150 per gram
        - **Canada**: $50 - $200 per gram
        - **South Africa**: $40 - $180 per gram
        - **Egypt**: No results
        - **Turkey**: $30 - $150 per gram
        - **Thailand**: $20 - $120 per gram
        - **Indonesia**: $20 - $120 per gram

        If no price range is provided for a country, it is marked as "No results." Prices are subject to change based on availability, supplier, and market conditions.
        MSDS
        MSDS
          Material Safety Data Sheet
        Section 1. Identification of the substance
            Product Name:      H-Thr-NH2 HCl    
            Synonyms:        L-Threonine amide hydrochloride    
        Section 2. Hazards identification
            Harmful by inhalation, in contact with skin, and if swallowed.
        Section 3. Composition/information on ingredients.
            Ingredient name:        H-Thr-NH2 HCl    
            CAS number:        33209-01-7    
        Section 4. First aid measures
            Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
            contaminated clothing and shoes. If irritation persists, seek medical attention.
            Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
            flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
            attention.
            Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
            Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    
        Section 5. Fire fighting measures
            In the event of a fire involving this material, alone or in combination with other materials, use dry
            powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
            should be worn.
        Section 6. Accidental release measures
            Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
            standards.
            Respiratory precaution:        Wear approved mask/respirator    
            Hand precaution:        Wear suitable gloves/gauntlets    
            Skin protection:        Wear suitable protective clothing    
            Eye protection:        Wear suitable eye protection    
            Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
            for disposal. See section 12.
            Environmental precautions: Do not allow material to enter drains or water courses.
        Section 7. Handling and storage
            Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
            in the handling and use of potentially hazardous chemicals, who should take into account the fire,
            health and chemical hazard data given on this sheet.
            Store in closed vessels.
            Storage:
        Section 8. Exposure Controls / Personal protection
            Engineering Controls: Use only in a chemical fume hood.
            Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
            General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
        Section 9. Physical and chemical properties
            Appearance:        Not specified    
            Boiling point:        No data    
            No data
            Melting point:
            Flash point:        No data    
            Density:        No data    
            Molecular formula:        C4H10N2O2.ClH    
            Molecular weight:        154.6    
        Section 10. Stability and reactivity
            Conditions to avoid: Heat, flames and sparks.
            Materials to avoid: Oxidizing agents.
            Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.
        Section 11. Toxicological information
            No data.
        Section 12. Ecological information
            No data.
        Section 13. Disposal consideration
            Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
            disposal authority, in accordance with national and regional regulations.
        Section 14. Transportation information
            Non-harzardous for air and ground transportation.
        Section 15. Regulatory information
            No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
            302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
            Title III, Section 313.

        SECTION 16 - ADDITIONAL INFORMATION
        N/A
        SDS 1.0
        H-THR-NH2 HCL Suppliers
        Company Name
        Business Type
        Location
        Details

        Sichuan Unibiochem Co., Ltd.
        中国
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