Search
Titanium Dioxide Acetic Acid Citric Acid Sodium Hydroxide Oxalic Acid Ethyl Acetate
Sign in/Join free

(CYS39)-TISSUE FACTOR (33-53)

CAS No.: 313642-01-2
Formula: C111H166N26O33S2
Molecular Weight: 2456.79
Suppliers: All(0) China Suppliers(0) Products(1)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Price
  • Related Product
  • Supplier Reference
What is (CYS39)-TISSUE FACTOR (33-53)

**Introduction to (Cys39)-Tissue Factor (33-53)** (Cys39)-Tissue Factor (33-53) is a synthetic peptide derived from the extracellular domain of human Tissue Factor (TF), a key initiator of the coagulation cascade. This modified peptide, incorporating a cysteine residue at position 39, is widely used in biochemical and medical research to study TF-mediated signaling pathways, thrombosis, and inflammation. Its high binding affinity for Factor VII/VIIa makes it valuable for investigating coagulation mechanisms and developing therapeutic interventions for thrombotic disorders. Additionally, (Cys39)-TF (33-53) serves as a critical tool in structural studies, antibody development, and drug discovery, offering insights into TF's role in hemostasis and disease. Its stability and specificity enhance its utility in both *in vitro* and *in vivo* applications. (100 words) Let me know if you'd like any refinements!

Preparation Process: To prepare (Cys39)-Tissue Factor (33-53), follow these steps: 1. **Solid-Phase Peptide Synthesis (SPPS)**: Use Fmoc chemistry to assemble the peptide sequence (residues 33–53 of Tissue Factor) on a resin. 2. **Cysteine Incorporation**: Introduce Cys at position 39 using Fmoc-Cys(Trt)-OH, with Trt protection to prevent disulfide formation. 3. **Side-Chain Deprotection**: Cleave the peptide from the resin and remove side-chain protections using TFA/water/TIS (95:2.5:2.5). 4. **Purification**: Purify the crude peptide via reversed-phase HPLC (C18 column, acetonitrile/water gradient). 5. **Lyophilization**: Lyophilize the purified peptide to obtain the final product. Verify purity and identity using mass spectrometry.

Usage Scenarios: The compound **(Cys39)-Tissue Factor (33-53)** is a synthetic peptide fragment derived from human tissue factor (TF), specifically residues 33–53 with a cysteine substitution at position 39. It is primarily used in biochemical and medical research to study the role of TF in coagulation, inflammation, and cancer progression. This peptide can modulate TF activity, serving as a tool to investigate TF-FVIIa interactions, downstream signaling pathways (e.g., PAR2 activation), and thrombotic disorders. It may also be employed in developing inhibitors for thrombosis or tumor-associated angiogenesis. Additionally, it aids in structural studies to understand TF's extracellular domain and its binding mechanisms.

(CYS39)-TISSUE FACTOR (33-53) Basic Info
Chemical Name (CYS39)-TISSUE FACTOR (33-53)
Synonyms PubChem ID: 90472031;(Cys??)-Tissue Factor (33-53);(CYS39)-TISSUE FACTOR (33-53);VAL-TYR-THR-VAL-GLN-ILE-CYS-THR-LYS-SER-GLY-ASP-TRP-LYS-SER-LYS-CYS-PHE-TYR-THR-THR;H-VAL-TYR-THR-VAL-GLN-ILE-CYS-THR-LYS-SER-GLY-ASP-TRP-LYS-SER-LYS-CYS-PHE-TYR-THR-THR-OH;H-Val-Tyr-Thr-Val-Gln-Ile-Cys-Thr-Lys-Ser-Gly-Asp-Trp-Lys-Ser-Lys-Cys-Phe-Tyr-Thr-Thr-OH, (Disulfide bond);(Cys39)-Tissue Factor (33-53) H-Val-Tyr-Thr-Val-Gln-Ile-Cys-Thr-Lys-Ser-Gly-Asp-Trp-Lys-Ser-Lys-Cys-Phe-Tyr-Thr-Thr-OH (Disulfide bond);L-Threonine,L-valyl-L-tyrosyl-L-threonyl-L-valyl-L-glutaminyl-L-isoleucyl-L-cysteinyl-L-threonyl-L-lysyl-L-serylglycyl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-seryl-L-lysyl-L-cysteinyl-L-phenylalanyl-L-tyrosyl-L-threonyl-,cyclic (7→17)-disulfide;L-Threonine, L-valyl-L-tyrosyl-L-threonyl-L-valyl-L-glutaminyl-L-isoleucyl-L-cysteinyl-L-threonyl-L-lysyl-L-serylglycyl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-seryl-L-lysyl-L-cysteinyl-L-phenylalanyl-L-tyrosyl-L-threonyl-, cyclic (7→17)-disulfide (9CI)
CAS No. 313642-01-2
Molecular Formula C111H166N26O33S2
Molecular Weight 2456.79
PSA 1032.00000
LogP 1.67560
Safely Info
RTECS -
Hazard Class -
Safety Statements -
HS Code -
WGK Germany -
Packing Group -
RIDADR -
Risk Statements -
Hazard Codes -
Caution Statement -
Hazard Declaration -
Symbol -
Signal Word -
(CYS39)-TISSUE FACTOR (33-53) Price
1. United States: $500 - $1,500
2. China: $300 - $1,000
3. Russia: $400 - $1,200
4. Germany: $600 - $1,800
5. India: $200 - $800
6. Japan: $700 - $2,000
7. Brazil: $350 - $1,100
8. South Korea: $500 - $1,500
9. Philippines: No results
10. United Kingdom: $600 - $1,800
11. France: $550 - $1,700
12. Mexico: $300 - $1,000
13. Canada: $500 - $1,500
14. South Africa: $250 - $900
15. Egypt: No results
16. Turkey: $400 - $1,200
17. Thailand: No results
18. Indonesia: No results
MSDS
SDS 1.0
Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (Cys39)-Tissue Factor (33-53)

1.2 Other means of identification

Product number -
Other names H-VAL-TYR-THR-VAL-GLN-ILE-CYS-THR-LYS-SER-GLY-ASP-TRP-LYS-SER-LYS-CYS-PHE-TYR-THR-THR-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
(Cys39)-Tissue Factor (33-53) (Cys39)-Tissue Factor (33-53) 313642-01-2 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state no data available
Colour no data available
Odour no data available
Melting point/ freezing point no data available
Boiling point or initial boiling point and boiling range no data available
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point no data available
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility no data available
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density no data available
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: no data available IMDG: no data available IATA: no data available

14.2 UN Proper Shipping Name

ADR/RID: no data available
IMDG: no data available
IATA: no data available

14.3 Transport hazard class(es)

ADR/RID: no data available IMDG: no data available IATA: no data available

14.4 Packing group, if applicable

ADR/RID: no data available IMDG: no data available IATA: no data available

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
(Cys39)-Tissue Factor (33-53) (Cys39)-Tissue Factor (33-53) 313642-01-2 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Not Listed.
EC Inventory Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.

16.Other information

Information on revision

Creation Date Aug 15, 2017
Revision Date Aug 15, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
(CYS39)-TISSUE FACTOR (33-53) Suppliers
Company Name
Business Type
Location
Details
Request For Quotation