VGVCCGYKLCHOC (O = hydroxyproline)

What is VGVCCGYKLCHOC (O = hydroxyproline)

VGVCCGYKLCHOC (O = hydroxyproline) is a synthetic peptide designed for advanced biomedical and therapeutic applications. This innovative compound features a unique sequence incorporating hydroxyproline, a modified amino acid known for its role in stabilizing collagen and enhancing structural integrity. The peptide’s design leverages its potential for targeted interactions with biological systems, making it a promising candidate for applications in tissue engineering, wound healing, and drug delivery. Its precise molecular structure allows for enhanced stability and bioavailability, ensuring optimal performance in research and clinical settings. VGVCCGYKLCHOC represents a cutting-edge tool in peptide-based therapeutics, offering new possibilities for addressing complex medical challenges.

Preparation Process: To prepare VGVCCGYKLCHOC (O = hydroxyproline), follow these steps: 1. **Solid-Phase Peptide Synthesis (SPPS)**: Use Fmoc chemistry on a resin (e.g., Wang or Rink amide). 2. **Amino Acid Coupling**: Sequentially couple Fmoc-protected residues (Val, Gly, Cys, Tyr, Lys, Leu, Cys, Hyp) with HBTU/HOBt/DIPEA in DMF. 3. **Cysteine Protection**: Use S-trityl or Acm for thiol protection. 4. **Hyp Incorporation**: Couple Fmoc-Hyp-OH like standard amino acids. 5. **Cleavage**: Treat with TFA/TIS/water (95:2.5:2.5) to release the peptide. 6. **Oxidative Folding**: Air-oxidize in ammonium bicarbonate buffer (pH 8) to form disulfide bonds (Cys-Cys). 7. **Purification**: Use RP-HPLC (C18 column, acetonitrile/water gradient). 8. **Lyophilization**: Freeze-dry the pure peptide.

Usage Scenarios: The compound VGVCCGYKLCHOC (O = hydroxyproline) is a synthetic peptide with potential applications in biomedical research and therapeutics. Its sequence suggests possible roles in cell adhesion, signaling, or modulation of protein-protein interactions. Hydroxyproline enhances stability and may improve collagen-like properties, making it relevant for tissue engineering or wound healing. The cysteine residues (C) could enable disulfide bond formation, influencing structural integrity or dimerization. The peptide may also serve as a substrate for enzyme studies or as a targeting ligand in drug delivery systems. Further research is needed to explore its specific biological activities and therapeutic potential.

VGVCCGYKLCHOC (O = hydroxyproline) Basic Info

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