ascorbic acid sulfate

What is ascorbic acid sulfate

Ascorbic acid sulfate is a stable, water-soluble derivative of vitamin C (ascorbic acid) that combines the antioxidant and immune-boosting properties of vitamin C with enhanced stability and bioavailability. Unlike traditional ascorbic acid, which is prone to oxidation and degradation, ascorbic acid sulfate is more resistant to environmental factors such as heat, light, and pH changes, making it an ideal choice for formulations requiring long-term stability. This compound is widely used in dietary supplements, skincare products, and pharmaceuticals, where it supports collagen synthesis, promotes skin health, and acts as a potent antioxidant to neutralize free radicals. Its unique properties make it a versatile and effective ingredient for health and wellness applications.

Preparation Process: To prepare **ascorbic acid sulfate**, dissolve **ascorbic acid (1.0 g, 5.68 mmol)** in **dry dimethylformamide (DMF, 10 mL)** under nitrogen. Add **sulfur trioxide-pyridine complex (1.8 g, 11.36 mmol)** in portions at **0°C**, stirring for **2 hours**. Warm the mixture to **room temperature** and stir for **6 hours**. Quench the reaction with **ice-cold water (50 mL)** and extract with **ethyl acetate (3 × 30 mL)**. Dry the combined organic layers over **anhydrous sodium sulfate**, filter, and concentrate under reduced pressure. Purify the crude product by **recrystallization (ethanol/water)** to obtain **ascorbic acid sulfate** as a white solid.

Usage Scenarios: Ascorbic acid sulfate is primarily used as a stable derivative of vitamin C (ascorbic acid), offering improved oxidation resistance for applications in pharmaceuticals, cosmetics, and food preservation. In skincare, it acts as an antioxidant, promoting collagen synthesis and skin brightening. In medicine, it serves as a prolonged-release form of vitamin C, aiding immune support and wound healing. Industrially, it functions as a reducing agent and stabilizer in chemical processes. Its sulfate group enhances solubility and bioavailability, making it useful in dietary supplements. Additionally, it is employed in research for studying vitamin C metabolism and oxidative stress mechanisms.

ascorbic acid sulfate Basic Info

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