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STYRENE-D8

CAS No.: 19361-62-7
Formula: C8D8
Molecular Weight: 112.2
Suppliers: All(0) China Suppliers(0) Products(0)
  • Description
  • Basic Info
  • Safety Info
  • MSDS
  • Price
What is STYRENE-D8

STYRENE-D8 is a deuterated analog of styrene, where all eight hydrogen atoms in the styrene molecule are replaced with deuterium, a stable isotope of hydrogen. This high-purity compound is widely used as an internal standard in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) due to its distinct isotopic signature, which enhances analytical precision. STYRENE-D8 is also employed in chemical research, particularly in studies involving polymerization mechanisms, reaction kinetics, and isotopic labeling. Its stability and unique properties make it an essential tool for scientists in organic chemistry, materials science, and pharmaceutical development, enabling accurate and reliable experimental results.

Preparation Process: The preparation of STYRENE-D8 involves the deuteration of styrene. Begin with ethylbenzene-D10, which is brominated to form 1-bromo-1-phenylethane-D8. This intermediate is then subjected to dehydrobromination using a strong base like potassium hydroxide (KOH) in ethanol, yielding STYRENE-D8. Alternatively, styrene can be directly deuterated using D2 gas over a platinum or palladium catalyst under high pressure and temperature. Purification is achieved via fractional distillation or column chromatography to ensure high isotopic purity (>98% D). All steps should be performed under inert conditions to prevent proton exchange. Use deuterated solvents to maintain isotopic integrity.

Usage Scenarios: STYRENE-D8 (deuterated styrene) is primarily used as an internal standard in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, due to its stable isotopic labeling. It aids in the accurate quantification of non-deuterated styrene in environmental, industrial, and biological samples by minimizing interference from matrix effects. The compound is also employed in polymerization studies to trace reaction mechanisms and kinetics without isotopic scrambling. Additionally, STYRENE-D8 serves as a reference material in metabolic research to track styrene degradation pathways. Its high isotopic purity ensures reliable results in chemical and pharmaceutical research involving styrene-based compounds.

STYRENE-D8 Basic Info
Chemical Name STYRENE-D8
Synonyms STYRENE-D8;(2H8)styrene;VINYLBENZENE;CinnaMene-d8;MaoMin SM-d8;NSC 62785-d8;PHENYLETHYLENE;Vinylbenzene-D8;(2H5)Phenylethene;Styrene-d8, stab.
CAS No. 19361-62-7
Molecular Formula C8D8
Molecular Weight 112.2
PSA 0.00000
LogP 2.32960
Safely Info
RTECS -
Hazard Class 3
Safety Statements 23-26
HS Code 28459000
WGK Germany -
Packing Group III
RIDADR UN 2055 3/PG 3
Risk Statements 10-20-36/38
Hazard Codes Xn
Caution Statement P202-P210-P303+P361+P353-P304+P340+P312-P305+P351+P338-P308+P313
Hazard Declaration H226-H315-H319-H332-H361-H372
Symbol GHS02,GHS07,GHS08
Signal Word Danger
STYRENE-D8 Price
Here is a rough price range for the chemical product "STYRENE-D8" in the 18 countries listed. Note that prices can vary significantly based on supplier, quantity, and market conditions:

- **United States**: $500 - $1,500 per gram
- **China**: $400 - $1,200 per gram
- **Russia**: $600 - $1,800 per gram
- **Germany**: $550 - $1,600 per gram
- **India**: $450 - $1,300 per gram
- **Japan**: $600 - $1,700 per gram
- **Brazil**: $700 - $2,000 per gram
- **South Korea**: $500 - $1,500 per gram
- **Philippines**: No results
- **United Kingdom**: $550 - $1,600 per gram
- **France**: $550 - $1,600 per gram
- **Mexico**: $700 - $2,000 per gram
- **Canada**: $500 - $1,500 per gram
- **South Africa**: No results
- **Egypt**: No results
- **Turkey**: $600 - $1,800 per gram
- **Thailand**: No results
- **Indonesia**: No results

These ranges are approximate and may not reflect real-time market conditions. Prices can vary based on purity, supplier, and quantity purchased.
MSDS
MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Styrene-d8    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 19361-62-7    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 3), H226
    Acute toxicity, Inhalation (Category 4), H332
    Skin irritation (Category 2), H315
    Eye irritation (Category 2), H319
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    R10
    Xn Harmful        R20    
    Xi Irritant        R36/38    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Warning    
    Hazard statement(s)
    H226        Flammable liquid and vapour.    
    H315        Causes skin irritation.    
    H319        Causes serious eye irritation.    
    H332        Harmful if inhaled.    
    Precautionary statement(s)
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard        none    
    Statements
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Substances
    Chemical characterization : Isotopically labeled
    Synonyms        : Vinylbenzene-D8    
    Phenylethylene-D8
    Deuterated styrene
    Formula        : C8D8    
    Molecular Weight        : 112,20 g/mol    
    CAS-No.        : 19361-62-7    
    EC-No.        : 242-995-6    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Styrene-d8
    CAS-No.        19361-62-7        Flam. Liq. 3; Acute Tox. 4;        <= 100 %    
    EC-No.        242-995-6        Skin Irrit. 2; Eye Irrit. 2; H226,    
    H315, H319, H332
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Styrene-d8
    CAS-No.        19361-62-7        Xn, R10 - R20 - R36/38        <= 100 %    
    EC-No.        242-995-6    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Beware of vapours accumulating to form explosive concentrations.
    Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Store under inert gas. hygroscopic
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: clear, liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: -31 °C    
    point
    f) Initial boiling point and 145 - 146 °C - lit.
    boiling range
    g) Flash point        31 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        0,979 g/mL at 25 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
    Contains the following stabiliser(s):
    4-tert-Butylpyrocatechol (<=0,01 %)
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    no data available
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
  Carcinogenicity
    IARC:        2B - Group 2B: Possibly carcinogenic to humans (Styrene-d8)    
  Reproductive toxicity
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated., Nausea, Headache, Vomiting, Central nervous system depression, Dermatitis

SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 2055        IMDG: 2055        IATA: 2055    
  UN proper shipping name
    ADR/RID: STYRENE MONOMER, STABILIZED
    IMDG: STYRENE MONOMER, STABILIZED
    IATA:        Styrene monomer, stabilized    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0