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COLLAGEN TYPE II FRAGMENT

CAS No.: 144703-90-2

Formula: C106H174N32O37

Molecular Weight: 2488.71

Suppliers: All(0) China Suppliers(0) Products(0)

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What is COLLAGEN TYPE II FRAGMENT

**Introduction to Collagen Type II Fragment** Collagen Type II Fragment is a bioactive peptide derived from native Type II collagen, a key structural protein found in cartilage and joint tissues. This specialized fragment is designed to support joint health by promoting cartilage repair, reducing inflammation, and enhancing mobility. Unlike full-length collagen, its smaller molecular size allows for better absorption and targeted action, making it highly effective in managing joint discomfort and stiffness. Backed by scientific research, Collagen Type II Fragment is ideal for individuals with active lifestyles, aging-related joint concerns, or those seeking natural joint support. Incorporate it into your wellness routine for improved flexibility and long-term joint resilience.

Preparation Process: To prepare **Collagen Type II Fragment**, follow these steps: 1. **Extraction**: Isolate **type II collagen** from cartilage (e.g., bovine or chicken) via enzymatic digestion (pepsin) in acidic conditions. 2. **Purification**: Centrifuge and precipitate collagen using salt (NaCl), then dialyze against acetic acid. 3. **Fragmentation**: Digest purified collagen with **matrix metalloproteinases (MMPs)** or **collagenase** to generate fragments. 4. **Size Separation**: Use **gel filtration chromatography** or **ultrafiltration** to isolate fragments of desired molecular weight. 5. **Lyophilization**: Freeze-dry the purified fragments for storage. 6. **Characterization**: Confirm fragment identity via **SDS-PAGE**, **HPLC**, or **mass spectrometry**. Adjust conditions for reproducibility.

Usage Scenarios: Collagen Type II Fragment is primarily used in medical research and therapeutic applications. It plays a key role in studying cartilage degradation and osteoarthritis due to its involvement in joint health. Researchers utilize it to investigate autoimmune responses, particularly in rheumatoid arthritis, as it may trigger immune reactions. The fragment is also employed in developing biomarkers for cartilage turnover and disease progression. In regenerative medicine, it aids in exploring tissue engineering and cartilage repair strategies. Additionally, it serves as a reference standard in immunoassays and diagnostic tests to detect collagen degradation products, helping assess joint disorders and monitor treatment efficacy.

COLLAGEN TYPE II FRAGMENT Basic Info

Chemical Name COLLAGEN TYPE II FRAGMENT

Synonyms COLLAGEN TYPE II FRAGMENT;(ALA260,HYP261,ASN263)-COLLAGEN TYPE II (245-270);Collagen Type II Fragment/(Ala2??,Hyp2?1,Asn2?3)-Collagen Type II (245-270);H-PRO-THR-GLY-PRO-LEU-GLY-PRO-LYS-GLY-GLN-THR-GLY-GLU-LEU-GLY-ALA-HYP-GLY-ASN-LYS-GLY-GLU-GLN-GLY-PRO-LYS-OH;L-Lysine, L-prolyl-L-threonylglycyl-L-prolyl-L-leucylglycyl-L-prolyl-L-lysylglycyl-L-glutaminyl-L-threonylglycyl-L-α-glutamyl-L-leucylglycyl-L-alanyl-(4R)-4-hydroxy-L-prolylglycyl-L-asparaginyl-L-lysylglycyl-L-α-glutamyl-L-glutaminylglycyl-L-prolyl- (9CI)

CAS No. 144703-90-2

Molecular Formula C106H174N32O37

Molecular Weight 2488.71

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COLLAGEN TYPE II FRAGMENT Price

Here is a rough price range for "Collagen Type II Fragment" in the 18 countries listed. Note that prices can vary significantly based on suppliers, purity, quantity, and market conditions:

1. **United States**: $100 - $500 per gram
2. **China**: $50 - $300 per gram
3. **Russia**: $80 - $400 per gram
4. **Germany**: $120 - $600 per gram
5. **India**: $40 - $250 per gram
6. **Japan**: $150 - $700 per gram
7. **Brazil**: $70 - $350 per gram
8. **South Korea**: $100 - $450 per gram
9. **Philippines**: No results
10. **United Kingdom**: $130 - $550 per gram
11. **France**: $120 - $600 per gram
12. **Mexico**: $60 - $300 per gram
13. **Canada**: $100 - $500 per gram
14. **South Africa**: No results
15. **Egypt**: No results
16. **Turkey**: $70 - $350 per gram
17. **Thailand**: $50 - $300 per gram
18. **Indonesia**: No results

These ranges are approximate and may vary depending on the source and market conditions. If no results are listed, it indicates that specific pricing data is unavailable or the product is not commonly traded in that market.