[D1]-stearic acid

What is [D1]-stearic acid

[D1]-stearic acid is a high-purity, isotopically labeled form of stearic acid, a saturated fatty acid widely used in research and industrial applications. This product is uniquely enriched with deuterium (D1) at a specific position, making it an invaluable tool for metabolic studies, lipid research, and tracer experiments. Its stable isotopic labeling allows for precise tracking and analysis of fatty acid metabolism, enabling researchers to gain deeper insights into biochemical pathways and lipid dynamics. [D1]-stearic acid is ideal for applications in nutrition science, pharmaceuticals, and biochemistry, offering exceptional accuracy and reliability. With its consistent quality and versatility, it is a trusted choice for advanced scientific investigations.

Preparation Process: To prepare [D1]-stearic acid, deuterium-labeled stearic acid, follow these steps: 1. **Deuterium Source**: Use deuterium gas (D₂) or deuterated reagents like D₂O or NaBD₄ for isotopic labeling. 2. **Reduction Method**: Hydrogenate oleic acid (cis-9-octadecenoic acid) with D₂ gas in the presence of a palladium or platinum catalyst to replace the double bond’s hydrogens with deuterium, yielding [9,10-D2]-stearic acid. 3. **Selective Labeling**: For [D1]-stearic acid, selectively deuterate a specific position using directed synthesis, such as Grignard reactions with deuterated alkyl halides or carboxylation of deuterated intermediates. 4. **Purification**: Isolate the product via recrystallization or column chromatography and confirm deuteration using NMR or mass spectrometry. (100 words)

Usage Scenarios: [D1]-stearic acid, a deuterium-labeled form of stearic acid, is primarily used as a stable isotopic tracer in metabolic and biochemical research. It enables scientists to track lipid metabolism, absorption, and distribution in vivo without altering chemical properties. This compound is valuable in studies involving fatty acid oxidation, lipid turnover, and membrane dynamics. Additionally, it aids in drug development by assessing the pharmacokinetics of lipid-based formulations. In nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses, [D1]-stearic acid serves as an internal standard for precise quantification. Its applications extend to nutrition science, where it helps investigate dietary fat utilization and metabolic disorders.

[D1]-stearic acid Basic Info

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