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lithocholic acid

CAS No.: 119248-96-3

Formula: C26H42O3

Molecular Weight: 402.61000

Suppliers: All(0) China Suppliers(5) Products(6)

Description
Basic Info
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Price

What is lithocholic acid

**Introduction to Lithocholic Acid** Lithocholic acid (LCA) is a secondary bile acid produced in the liver by the bacterial metabolism of primary bile acids, such as chenodeoxycholic acid. As a hydrophobic bile acid, LCA plays a role in lipid digestion and absorption. It also acts as a signaling molecule, modulating metabolic pathways through receptors like the farnesoid X receptor (FXR) and TGR5. Recent research highlights its potential in regulating inflammation, glucose metabolism, and gut microbiota balance. However, high concentrations of LCA may be cytotoxic and linked to liver disorders. Due to its biological significance, LCA is studied for therapeutic applications in metabolic diseases, cancer, and microbiome-related conditions.

Preparation Process: Lithocholic acid can be prepared via the following method: 1. **Starting Material**: Begin with chenodeoxycholic acid (3α,7α-dihydroxy-5β-cholan-24-oic acid). 2. **Selective Dehydroxylation**: Treat chenodeoxycholic acid with sodium hydroxide (NaOH) and a reducing agent (e.g., hydrazine or Pd/C under hydrogen) to remove the 7α-hydroxyl group while retaining the 3α-hydroxyl group. 3. **Purification**: Isolate the product via acidification, extraction with organic solvents (e.g., ethyl acetate), and recrystallization from ethanol or methanol. 4. **Characterization**: Confirm purity using TLC, HPLC, or NMR spectroscopy. This yields lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid).

Usage Scenarios: Lithocholic acid (LCA) is a secondary bile acid produced by bacterial metabolism of primary bile acids in the gut. It plays a role in fat digestion by emulsifying dietary lipids. LCA also acts as a signaling molecule, modulating the farnesoid X receptor (FXR) and TGR5 receptors, influencing bile acid homeostasis, glucose metabolism, and inflammation. It exhibits antimicrobial properties, helping regulate gut microbiota. In research, LCA is used to study liver and metabolic diseases, including cholestasis and non-alcoholic fatty liver disease (NAFLD). Additionally, it has potential therapeutic applications in treating metabolic disorders and as a biomarker for bile acid-related pathologies.

lithocholic acid Basic Info

Chemical Name lithocholic acid

Synonyms 3-Oxo-5β-cholan-24-saeure-aethylester; 3-oxo-5β-cholan-24-oic acid ethyl ester; ethyl 3-oxo-5β-cholan-24-oate; (5β)-3-oxocholan-24-oic acid ethyl ester; (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid ethyl ester

CAS No. 119248-96-3

Molecular Formula C26H42O3

Molecular Weight 402.61000

PSA 43.37000

LogP 6.19380

lithocholic acid Price

Here is a rough price range for lithocholic acid in the listed countries. Note that prices can vary based on supplier, purity, quantity, and market conditions. If no specific data is available, it is marked as "No results":

- **United States**: $50 - $200 per gram
- **China**: $30 - $150 per gram
- **Russia**: $40 - $180 per gram
- **Germany**: $60 - $220 per gram
- **India**: $20 - $120 per gram
- **Japan**: $70 - $250 per gram
- **Brazil**: $50 - $200 per gram
- **South Korea**: $60 - $230 per gram
- **Philippines**: No results
- **United Kingdom**: $70 - $240 per gram
- **France**: $65 - $230 per gram
- **Mexico**: $40 - $180 per gram
- **Canada**: $55 - $210 per gram
- **South Africa**: No results
- **Egypt**: No results
- **Turkey**: $35 - $160 per gram
- **Thailand**: $25 - $140 per gram
- **Indonesia**: No results

These ranges are approximate and may not reflect real-time market conditions. For accurate pricing, consult suppliers or distributors in each country.