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TCO-carbonate

CAS No.: 1191901-33-3

Formula: C13H17NO5

Molecular Weight: 267.28

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What is TCO-carbonate

**Introduction to TCO-Carbonate** TCO-Carbonate is a high-performance, thermally conductive material designed for advanced thermal management applications. Composed of a specialized carbonate-based matrix infused with thermally conductive fillers, it offers exceptional heat dissipation, electrical insulation, and mechanical stability. Ideal for electronics, energy storage systems, and industrial applications, TCO-Carbonate ensures efficient thermal regulation, enhancing device reliability and longevity. Its lightweight, corrosion-resistant properties make it suitable for demanding environments, while its customizable formulation allows for tailored solutions based on specific thermal and structural requirements. By improving heat transfer efficiency, TCO-Carbonate helps optimize performance in high-power devices, contributing to energy efficiency and sustainability in modern technologies.

Preparation Process: To prepare TCO-carbonate, first synthesize trans-cyclooctene (TCO) by reacting cyclooctadiene with a dienophile via a Diels-Alder reaction, followed by hydrogenation. Next, activate the TCO hydroxyl derivative (e.g., TCO-OH) with carbonyl diimidazole (CDI) in anhydrous dichloromethane (DCM) under nitrogen for 1 hour at room temperature. Then, add a carbonate precursor (e.g., 4-nitrophenyl chloroformate) and triethylamine, stirring for 4–6 hours. Purify the crude product via silica gel chromatography, eluting with a gradient of ethyl acetate/hexane. Characterize by NMR and MS. Store at −20°C under inert conditions.

Usage Scenarios: TCO-carbonate is a versatile compound primarily used in bioorthogonal chemistry for labeling and modifying biomolecules. Its trans-cyclooctene (TCO) group enables rapid, selective reactions with tetrazines via inverse electron-demand Diels-Alder (IEDDA) click chemistry, making it valuable for live-cell imaging, drug delivery, and targeted therapy. The carbonate moiety enhances stability and solubility, facilitating conjugation with drugs, antibodies, or nanoparticles. It is widely applied in pretargeted radioimmunotherapy, where TCO-tagged biomolecules bind to tetrazine-functionalized radioligands for precise tumor targeting. Additionally, TCO-carbonate is used in proteomics for selective protein labeling and in diagnostics for high-sensitivity detection assays. Its biocompatibility and fast kinetics make it ideal for dynamic biological studies.

TCO-carbonate Basic Info

Chemical Name TCO-carbonate

Synonyms TCO-NHS;TCO-carbonate;TCO-NHS ester;(4E)-TCO-NHS ester;1191901-33-3(Mixture);TCONHS ester,TCO NHS ester;TCO-N-hydroxysuccinimidyl carbonate;TCO4 - NHS carbonate / AXIAL isomer;TCO4 - NHS carbonate / EQUATORIAL isomer;TCO-NHS Ester,Trans-Cyclooctene-NHS ester

CAS No. 1191901-33-3

Molecular Formula C13H17NO5

Molecular Weight 267.28

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TCO-carbonate Price

Here is a rough price range for the chemical product "TCO-carbonate" in the 18 countries listed. Note that these ranges are hypothetical and based on general market trends for specialty chemicals. If no specific data is available, it is marked as "No results":

1. **United States**: $50 - $150 per kilogram
2. **China**: $30 - $100 per kilogram
3. **Russia**: $40 - $120 per kilogram
4. **Germany**: $60 - $160 per kilogram
5. **India**: $25 - $90 per kilogram
6. **Japan**: $70 - $180 per kilogram
7. **Brazil**: $35 - $110 per kilogram
8. **South Korea**: $55 - $140 per kilogram
9. **Philippines**: No results
10. **United Kingdom**: $65 - $170 per kilogram
11. **France**: $60 - $160 per kilogram
12. **Mexico**: $30 - $100 per kilogram
13. **Canada**: $50 - $150 per kilogram
14. **South Africa**: $40 - $120 per kilogram
15. **Egypt**: No results
16. **Turkey**: $35 - $110 per kilogram
17. **Thailand**: $30 - $100 per kilogram
18. **Indonesia**: No results

These ranges are approximate and can vary based on factors like supply chain, demand, and local market conditions. For accurate pricing, consult local suppliers or market reports.