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HOLO-TRANSFERRIN

CAS No.: 11096-37-0

Formula: C16H22N6O4

Molecular Weight: 362.38368

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What is HOLO-TRANSFERRIN

**Introduction to HOLO-TRANSFERRIN** HOLO-TRANSFERRIN is a high-purity, iron-saturated form of transferrin, a critical glycoprotein essential for iron transport and cellular uptake. This biologically active protein plays a vital role in maintaining iron homeostasis, supporting cell growth, and ensuring efficient iron delivery in research and biopharmaceutical applications. With exceptional stability and consistency, HOLO-TRANSFERRIN is ideal for cell culture, diagnostic assays, and therapeutic development. Its iron-binding capacity enhances cell proliferation and differentiation, making it invaluable in stem cell research, cancer studies, and regenerative medicine. Rigorously tested for purity and performance, HOLO-TRANSFERRIN ensures reliable results, making it a trusted choice for scientists and manufacturers in biotechnology and life sciences.

Preparation Process: To prepare **holo-transferrin**, dissolve **apo-transferrin** (iron-free) in a buffer (e.g., 20 mM HEPES or Tris, pH 7.4–8.0). Add a **2:1 molar ratio of ferric iron (Fe³⁺)** as **ferric ammonium citrate** or **ferric nitrilotriacetate (Fe-NTA)**. Incubate at **37°C for 1–2 hours** with gentle agitation. Ensure **bicarbonate (5–10 mM)** is present to facilitate iron binding. Remove excess iron via **dialysis** (against buffer) or **gel filtration chromatography**. Confirm iron saturation using **UV-Vis spectroscopy** (absorbance at 465 nm). Sterilize by **0.22 µm filtration** and store at **4°C** or **–20°C**. Maintain **iron:protein ratio** for optimal functionality.

Usage Scenarios: Holo-transferrin is the iron-bound form of transferrin, a glycoprotein essential for iron transport in the bloodstream. It binds and delivers iron to cells via transferrin receptors, regulating iron homeostasis and preventing oxidative damage from free iron. Clinically, holo-transferrin is used to treat iron deficiency anemia by replenishing iron stores safely. It also serves as a biomarker for iron metabolism disorders. In research, holo-transferrin is employed to study cellular iron uptake, receptor-mediated endocytosis, and conditions like hemochromatosis or cancer, where iron metabolism is dysregulated. Additionally, it aids in drug delivery systems by targeting cells with high transferrin receptor expression.

HOLO-TRANSFERRIN Basic Info

Chemical Name HOLO-TRANSFERRIN

Synonyms HOLO;Optiferrin;ransferrin;SIDEROPHILIN;transferrins;APO-TRANSFERRIN;HOLO-TRANSFERRIN;HUMAN TRASFERRIN;Holotransferrins;HUMAN TRANSFERRIN

CAS No. 11096-37-0

Molecular Formula C16H22N6O4

Molecular Weight 362.38368

PSA -

LogP -

Safely Info

RTECS -

Hazard Class -

Safety Statements 26-37/39

HS Code 3002120000

WGK Germany -

Packing Group -

RIDADR -

Risk Statements 36/37/38

Hazard Codes B,Xi

Caution Statement P280-P264

Hazard Declaration H315-H319-H335

Symbol GHS07

Signal Word Warning

HOLO-TRANSFERRIN Price

1. United States: $50 - $200 per mg
2. China: $30 - $150 per mg
3. Russia: $40 - $180 per mg
4. Germany: $60 - $220 per mg
5. India: $20 - $120 per mg
6. Japan: $70 - $250 per mg
7. Brazil: $35 - $160 per mg
8. South Korea: $50 - $200 per mg
9. Philippines: No results
10. United Kingdom: $60 - $230 per mg
11. France: $65 - $240 per mg
12. Mexico: $30 - $140 per mg
13. Canada: $55 - $210 per mg
14. South Africa: $25 - $130 per mg
15. Egypt: No results
16. Turkey: $35 - $150 per mg
17. Thailand: $20 - $110 per mg
18. Indonesia: No results