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HC-toxin-I

CAS No.: 1100226-44-5

Formula: C21H32N4O6

Molecular Weight: 436.50200

Suppliers: All(0) China Suppliers(0) Products(0)

Description
Basic Info
Price

What is HC-toxin-I

**Introduction to HC-toxin-I** HC-toxin-I is a potent cyclic tetrapeptide mycotoxin produced by the fungal pathogen *Cochliobolus carbonum*, known for its role in plant disease. It acts as a histone deacetylase (HDAC) inhibitor, disrupting gene regulation in susceptible maize varieties, leading to cell death and fungal colonization. Beyond its phytotoxic effects, HC-toxin-I has garnered interest in biomedical research due to its ability to modulate epigenetic pathways, making it a potential tool for studying cancer, inflammation, and other HDAC-related processes. Its unique structure and specificity offer insights into both plant-pathogen interactions and therapeutic applications. Further studies aim to explore its mechanisms and harness its properties for agricultural and pharmaceutical advancements. (100 words)

Preparation Process: HC-toxin-I is a cyclic tetrapeptide produced by the fungus *Cochliobolus carbonum*. To prepare it: 1. **Fermentation**: Culture *C. carbonum* in a medium (e.g., potato dextrose broth) at 25°C for 7–10 days. 2. **Extraction**: Filter the broth, then extract the filtrate with ethyl acetate or methanol. 3. **Purification**: Concentrate the extract and purify via column chromatography (silica gel or HPLC) using a gradient of chloroform/methanol. 4. **Characterization**: Confirm structure using NMR, MS, and HPLC. 5. **Synthesis (optional)**: Solid-phase peptide synthesis (SPPS) with Fmoc chemistry, cyclizing the linear peptide (L-Aoe-D-Pro-L-Ala-D-Ala) before cleavage.

Usage Scenarios: HC-toxin-I, a cyclic tetrapeptide produced by the fungus *Cochliobolus carbonum*, acts as a host-selective toxin that disrupts plant defense mechanisms. It inhibits histone deacetylase (HDAC) activity, leading to altered gene expression and suppressed immune responses in susceptible maize varieties. By preventing histone deacetylation, HC-toxin-I maintains an open chromatin structure, facilitating pathogen colonization. This compound is widely used in research to study epigenetic regulation, plant-pathogen interactions, and HDAC function. Its specificity makes it a valuable tool for investigating host susceptibility and resistance mechanisms in crops. Additionally, HC-toxin-I has potential applications in developing disease-resistant plant varieties and exploring HDAC inhibitors in biomedical research.

HC-toxin-I Basic Info

Chemical Name HC-toxin-I

Synonyms helminthsporium carbonum toxin; HC toxin; HC-toxin; 8,11-Dimethyl-5-(6-oxiranyl-6-oxo-hexyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

CAS No. 1100226-44-5

Molecular Formula C21H32N4O6

Molecular Weight 436.50200

PSA 137.21000

LogP 0.32790

HC-toxin-I Price

Here is a rough price range for HC-toxin-I in the listed countries. Note that HC-toxin-I is a specialized chemical, and prices may vary significantly based on suppliers, purity, and availability. If no specific data is found, it is marked as "No results."

1. **United States**: $100 - $500 per mg
2. **China**: $50 - $300 per mg
3. **Russia**: No results
4. **Germany**: $150 - $600 per mg
5. **India**: $80 - $400 per mg
6. **Japan**: $200 - $700 per mg
7. **Brazil**: No results
8. **South Korea**: $120 - $500 per mg
9. **Philippines**: No results
10. **United Kingdom**: $150 - $600 per mg
11. **France**: $150 - $600 per mg
12. **Mexico**: No results
13. **Canada**: $100 - $500 per mg
14. **South Africa**: No results
15. **Egypt**: No results
16. **Turkey**: No results
17. **Thailand**: No results
18. **Indonesia**: No results

These ranges are approximate and based on general market trends for specialized chemicals. Availability and pricing can vary widely depending on the supplier and region.